ArticleTranslational psychiatry2022
Insulinopathies of the brain? Genetic overlap between somatic insulin-related and neuropsychiatric disorders.
Article in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Systematic Review: Convergence and Divergence Between Autism Spectrum Disorder and Obsessive-Compulsive Disorder: Genetic, Neuroimaging, and Cognitive Findings.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Pooled it
- Neuroimaging Insights into the Public Health Burden of Neuropsychiatric Disorders: A Systematic Review of Electroencephalography-Based Cognitive Biomarkers.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Insulin resistance in depression: A large meta-analysis of metabolic parameters and variation.Neuroscience and biobehavioral reviews · 2022Pooled it
- Genetic overlap and shared risk loci between autism spectrum disorder and cardiometabolic traits.Molecular psychiatry · 2026Article
- Metabolic Dysregulation in ADHD: Implications for Appetite, Sleep, Stress Reactivity, and Pharmacological Treatment.Metabolites · 2026Review
- How does type 2 diabetes modify the risk of Alzheimer's disease?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Symptom-specific genetics reveal heterogeneity within major depressive disorder.medRxiv : the preprint server for health sciences · 2026Article
- Association between the triglyceride to high-density lipoprotein cholesterol ratio and 90-day post-stroke depression in acute ischemic stroke.Frontiers in psychiatry · 2026Article
- The mechanisms underlying COVID-19 induced insulin resistance: a narrative review.Frontiers in endocrinology · 2026Review
- Shared genetic architecture between psychiatric and insulin-related traits in the general population.Neuroscience applied · 2026Article
- The moderating role of diet and physical activity in insulin resistance and immunometabolic depression.Scientific reports · 2025Article
- Drivers of hypoglycaemia in anorexia nervosa: Clinical severity, BMI, and illness duration.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Distinct neuroimaging subtypes of ADHD among adolescents based on semi-supervised learning.Translational psychiatry · 2025Article
- Evidence of bidirectional relationship between type 2 diabetes and depression; a Mendelian randomization study.Molecular psychiatry · 2025Article
- An interoceptive model of energy allostasis linking metabolic and mental health.Science advances · 2025Review
- Association of genetic scores related to insulin resistance with neurological outcomes in ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program.Communications biology · 2025Article
- A pilot study examining a ketogenic diet as an adjunct therapy in college students with major depressive disorder.Translational psychiatry · 2025Article
- Genetic factors and symptom dimensions associated with antidepressant treatment outcomes: clues for new potential therapeutic targets?European archives of psychiatry and clinical neuroscience · 2025Review
- Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies-A Narrative Review.International journal of molecular sciences · 2025Review
- Local patterns of genetic sharing between neuropsychiatric and insulin resistance-related conditions.Translational psychiatry · 2025Article
Corrections and comments
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Authors and funding
16 authors at 8 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of somatic insulinopathies, like metabolic syndrome (MetS), obesity, and type 2 diabetes mellitus (T2DM), is higher in Alzheimer's disease (AD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD). Dysregulation of insulin signalling has been implicated in these neuropsychiatric disorders, and shared genetic factors might partly underlie this observed multimorbidity. We investigated the genetic overlap between AD, ASD, and OCD with MetS, obesity, and T2DM by estimating pairwise global genetic correlations using the summary statistics of the largest available genome-wide association studies for these phenotypes. Having tested these hypotheses, other potential brain "insulinopathies" were also explored by estimating the genetic relationship of six additional neuropsychiatric disorders with nine insulin-related diseases/traits. Stratified covariance analyses were then performed to investigate the contribution of insulin-related gene sets. Significant negative genetic correlations were found between OCD and MetS (r
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.