ArticlePediatric rheumatology online journal2022
Exploring the intersection of adverse childhood experiences, pediatric chronic pain, and rheumatic disease.
Article in Pediatric rheumatology online journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05422456 (The Turkish Adaptation, Validity, and Reliability of the Functional Disability Inventory), which is not on this map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Turkish Adaptation, Validity, and Reliability of the Functional Disability Inventory
Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Prevalence and transient impact of childhood abuse and neglect on health-related quality of life in Mexican patients with early rheumatoid arthritis.Clinical rheumatology · 2026Article
- Adverse childhood experiences are associated with disease and mental health outcomes in childhood-onset SLE.Lupus science & medicine · 2026Article
- Sociodemographic differences in the prevalence of recurrent extremity pain in Icelandic schoolchildren: results from the WHO-collaborative Health Behaviour in School-aged Children (HBSC) cross-sectional survey.BMC public health · 2026Article
- Medical Post-Traumatic Stress Disorder Symptoms in Children and Adolescents with Chronic Inflammatory Arthritis: Prevalence and Associated Factors.Children (Basel, Switzerland) · 2025Article
- Increase in stress contributes to impaired jaw function in juvenile idiopathic arthritis: a two-year prospective study.Pediatric rheumatology online journal · 2024Article
- Perceived mistreatment in patients with rheumatic diseases: The impact of the underlying diagnosis.PloS one · 2024Article
- Adverse childhood experiences and trauma informed care for chiropractors: a call to awareness and action.Chiropractic & manual therapies · 2023Article
- Anorexia Nervosa in Juvenile Systemic Lupus Erythematosus (SLE): A Causality Dilemma.Children (Basel, Switzerland) · 2023Review
- Family structure and multisite musculoskeletal pain in adolescence: a Northern Finland Birth Cohort 1986 study.BMC musculoskeletal disorders · 2023Article
- Can adverse childhood experiences predict chronic health conditions? Development of trauma-informed, explainable machine learning models.Frontiers in public health · 2023Article
- Rheumatic heart disease in school-attending Nepalese children: A descriptive analysis of the national heart screening database.Indian heart journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile the general relationship between ACEs and the development of chronic pain has become increasingly clear, how ACEs may shape a child's clinical presentation with regards to chronic pain has yet to be fully expounded. We aimed to determine the association between ACEs and clinical manifestations of pediatric chronic pain and explore the interaction of ACEs and pediatric rheumatic disease among youth with chronic pain on health-related outcomes.
methodsWe conducted a cross-sectional cohort study of patients aged ≤18 years with chronic pain seen in a pediatric rheumatology amplified pain clinic between August 2018 and July 2020. We stratified subjects into three groups: no ACEs, one ACE, and ≥ 2 ACEs. We assessed clinical signs and symptoms associated with the presence of ACEs using Chi-square or Wilcoxon-rank test. The association between ACEs as well as other variables of interest with functional impairment was tested using simple and multivariable linear regression.
resultsOf the 412 patients included, more than 75% of patients reported at least one ACE. Most frequent included history of mental illness in a first degree relative (56%) and parental divorce or separation (20%). Those with ≥2 ACEs had more somatic symptoms, worse functional disability, and a higher proportion of mental health conditions. There appeared to be a dose dependent interaction between ACEs and functional disability from co-morbid rheumatologic disease. In multivariable regression, higher verbal pain score, symptom severity score (SSS), and presence of autonomic changes were associated with estimated average increase in FDI score (β = 1.05, 1.95 and 4.76 respectively; all p < 0.01).
conclusionChildren with chronic pain and/or rheumatologic diseases who are exposed to ACEs are at increased risk of greater symptomatology, functional disability, and somatization of symptoms. Our findings indicate an ongoing need for systemic evaluation of ACEs in children with chronic pain and/or rheumatic disease and incorporation of trauma-based care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.