Observational studyBMC infectious diseases2022
Analysing the protection from respiratory tract infections and allergic diseases early in life by human milk components: the PRIMA birth cohort.
Observational study in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Severity of respiratory syncytial virus through the COVID-19 pandemic among infants aged ≤2 months: a secondary analysis of the IRIDE cohort study.Pediatric research · 2026Observational
- Maternal Dietary Fiber Intake During Lactation and Human Milk Oligosaccharide Fucosylation: a PRIMA Birth Cohort Study.Molecular nutrition & food research · 2025Article
- In Vivo Evidence on the Emerging Potential of Non-Digestible Oligosaccharides as Therapeutic Agents in Bacterial and Viral Infections.Nutrients · 2025Review
- Observational
- BREASTFEEDING AND ACUTE RESPIRATORY INFECTION (ARI) IN INFANTS: A SYSTEMATIC REVIEW IN NIGERIA.Annals of Ibadan postgraduate medicine · 2024Review
- Human breastmilk memory T cells throughout lactation manifest activated tissue-oriented profile with prominent regulation.JCI insight · 2024Article
- The Link between Different Types of Prebiotics in Infant Formula and Infection Rates: A Review.Nutrients · 2023Review
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Authors and funding
21 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundMany studies support the protective effect of breastfeeding on respiratory tract infections. Although infant formulas have been developed to provide adequate nutritional solutions, many components in human milk contributing to the protection of newborns and aiding immune development still need to be identified. In this paper we present the methodology of the "Protecting against Respiratory tract lnfections through human Milk Analysis" (PRIMA) cohort, which is an observational, prospective and multi-centre birth cohort aiming to identify novel functions of components in human milk that are protective against respiratory tract infections and allergic diseases early in life.
methodsFor the PRIMA human milk cohort we aim to recruit 1000 mother-child pairs in the first month postpartum. At one week, one, three, and six months after birth, fresh human milk samples will be collected and processed. In order to identify protective components, the level of pathogen specific antibodies, T cell composition, Human milk oligosaccharides, as well as extracellular vesicles (EVs) will be analysed, in the milk samples in relation to clinical data which are collected using two-weekly parental questionnaires. The primary outcome of this study is the number of parent-reported medically attended respiratory infections. Secondary outcomes that will be measured are physician diagnosed (respiratory) infections and allergies during the first year of life. DISCUSSION: The PRIMA human milk cohort will be a large prospective healthy birth cohort in which we will use an integrated, multidisciplinary approach to identify the longitudinal effect human milk components that play a role in preventing (respiratory) infections and allergies during the first year of life. Ultimately, we believe that this study will provide novel insights into immunomodulatory components in human milk. This may allow for optimizing formula feeding for all non-breastfed infants.
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