ArticleClinical and experimental immunology1986
Patterns of autoreactivity to collagen type II in autoimmune MRL/l mice.
Article in Clinical and experimental immunology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Protective and Pathogenic Antibodies to Citrullinated Antigens.Immunological reviews · 2026Review
- The systemic lupus erythematosus-associated NCF1Nature communications · 2025Article
- Autoimmune reaction to type II collagen and cartilage degeneration in MRL/Mp- lpr/lpr mouse.Rheumatology international · 2004Article
- Rheumatoid arthritis: a synovial disease?Annals of the rheumatic diseases · 1999Review
- Article
- Genetic, hormonal and behavioural influence on spontaneously developing arthritis in normal mice.Clinical and experimental immunology · 1992Article
- An idiotypic network model of AIDS immunopathogenesis.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Frequency and phenotypic feature of autoantibody-producing cell precursors in the preclinical stage of murine lupus.Immunology · 1990Article
- Sialadenitis in the MRL-l mouse: morphological and immunohistochemical characterization of resident and infiltrating cells.Immunology · 1987Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kinetics and mechanisms for secretion of antibodies against native and denatured collagen type II have been studied in spontaneously arthritic MRL/l mice. Circulating antibodies were quantified by an ELISA assay and frequencies of specific antibody secreting spleen cells by an ELISPOT assay. The degree of humoral immunity to collagen type II increased at late stages of the disease (6 months of age) whereas severe synovitis was seen earlier (5 months of age). Both the appearance of anti-collagen II producing cells and development of synovitis was preceded by and not correlated with a general state of polyclonal B cell activation. In MRL/l mice, collagen II specific antibodies appeared spontaneously and titres were largely unaffected by collagen II immunization. The levels of circulating anti-collagen II antibodies in MRL/l mice were lower, and the antibodies displayed lower avidities and different specificities as compared with the antibodies generated in collagen II high responder DBA/l mice after immunization with collagen II. It is suggested that the antibody response in MRL/l mice against collagen type II does not need MHC-restricted T cell help and that induction of antibody production to collagen II in MRL/l mice is triggered by joint cartilage destruction and subsequent collagen II release.
Indexed as
Identifiers
3516469PMC1577362W273512326What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.