ArticlemBio2021
The Human Nose Organoid Respiratory Virus Model: an
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06120244 (Establishment of a Biobank of Nasal Epithelium Samples From Healthy Volunteers), which is not on this map. Cited by 55 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Establishment of a Biobank of Nasal Epithelium Samples From Healthy Volunteers
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Lung Organoids: Systematic Review of Recent Advancements and its Future Perspectives.Tissue engineering and regenerative medicine · 2024Pooled it
- Mucosal immunization with an adenoviral vector expressing a prefusogenic F protein protects the upper and lower respiratory tracts of cotton rats against live respiratory syncytial virus challenge.Human vaccines & immunotherapeutics · 2026Article
- Review
- Human airway organoids for bacterial-host interaction studies: methods, insights and translational promise.Thorax · 2026Review
- RSV can infect the human nasal epithelium via the basolateral route and shows distinct subgroup infectivity and basal cell tropism.Journal of virology · 2026Article
- Generation of apical-out nasal organoids to facilitate human respiratory syncytial virus infection and drug screening.iScience · 2026Article
- Advances in Detection Methods for Human Respiratory Syncytial Virus Neutralizing Antibodies.Vaccines · 2026Review
- D-alanine aminotransferase (Dat) promotesbioRxiv : the preprint server for biology · 2026Article
- Lung organoids as a human system for Mycobacteria infection modeling and drug testing.The FEBS journal · 2026Review
- Organoids Gone Viral: A Comprehensive Review on Human Organoid Models to Study Viral Pathogenesis.Viruses · 2026Review
- Article
- Advances in human respiratory organoid models for studying the pathogenesis and intervention strategies of COVID-19.Virologica Sinica · 2026Review
- Investigating the Role of A20 in Respiratory Syncytial Virus Immunopathogenesis in a BALB/c Mouse Model.Immunity, inflammation and disease · 2026Article
- Research Advances and Disease Modeling in Respiratory Organoids.Biomedicines · 2026Review
- Molecular mechanism of resistance to lonafarnib conferred by mutations in the cysteine-rich region of respiratory syncytial virus fusion glycoprotein and discovery of a lonafarnib-derived antiviral PROTAC.Journal of virology · 2026Article
- Respiratory syncytial virus (RSV) antibody and small-molecule drugs: current status of clinical translation and challenges.Frontiers in microbiology · 2026Review
- Human organoids and organ-on-chip systems for AI-guided therapeutic discovery against emerging and re-emerging infections.Frontiers in pharmacology · 2026Review
- Differential antiviral effects and immune responses in nasal and airway organoid during RSV infection: implications for interferon therapy.Frontiers in immunology · 2026Article
- Generation of human-induced pluripotent stem cell-derived lung organoids for modeling respiratory syncytial virus infection and pulmonary injury.Frontiers in immunology · 2026Article
- Post-Translational Modifications in Respiratory Virus Infection: Recent Insights into the Development of In Vitro Models.International journal of molecular sciences · 2025Review
Corrections and comments
- Update of
Authors and funding
21 authors at 1 institution in 1 country.
Anubama RajanDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Ashley Morgan Weaver *Department of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Gina Marie Aloisio *Department of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Joseph JelinskiDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Hannah L JohnsonAdvanced Technology Cores, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Susan F VenableDepartment of Pathology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Trevor McBrideDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Letisha AideyanDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Felipe-Andrés PiedraDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Xunyan YeDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Ernestina Melicoff-PortilloDepartment of Pediatrics, Pulmonary Medicine Service, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Malli Rama Kanthi YerramilliDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Xi-Lei ZengDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Michael A ManciniAdvanced Technology Cores, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Fabio StossiAdvanced Technology Cores, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Anthony W MaressoDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Shalaka A KotkarEnvironmental Safety Department, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Mary K EstesDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.ORCID 0000-0002-4813-4249
Sarah BluttDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Vasanthi AvadhanulaDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Pedro A PiedraDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.ORCID 0000-0002-0100-2919
Baylor College of Medicine · US
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9MViral Diversity and Pathogenicity in Mucosal Respiratory and Gastrointestinal DiseaseU19AI144297 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI ESTES, MARY KOLB, GIBBS, RICHARD A · 2019 to 2024
$30.1MTissue Analysis & Molecular Imaging CoreP30DK056338 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Hashem B El-Serag · 2001 to 2026
$28.3MTranslational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Cheryl L. Walker · 2019 to 2026
$14.7MNovel Platforms for Human Intestinal Enteroids: Matrix, Mechanics, and TopographyU19AI116497 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MARESSO, ANTHONY W · 2015 to 2025
$13.2MResearch Training in Infections and ImmunityT32AI055413 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI GIORDANO, THOMAS P, MYSOREKAR, INDIRA U · 2003 to 2024
$3.2MNCI NIH HHS P30 CA125123NIAID NIH HHS T32 AI055413NIAID NIH HHS U19 AI116497NIAID NIH HHS U19 AI144297NIDDK NIH HHS P30 DK056338NIEHS NIH HHS P30 ES030285
Abstract
There is an unmet need for preclinical models to understand the pathogenesis of human respiratory viruses and predict responsiveness to immunotherapies. Airway organoids can serve as an
Indexed as
COVID-19Respiratory Syncytial Virus, HumanRespiratory Syncytial Virus InfectionsHumansInfantLungOrganoidsPalivizumabSARS-CoV-2Palivizumabair-liquid interface (ALI) cultureairwayairway organoidsALI culturesciliacytokinesepitheliumimmunoprophylaxismucusnose organoidspalivizumabrespiratory syncytial virus (RSV)RSVSARS-CoV-2severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)therapeutics
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT06120244ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.