Evidence map›Paper›PMID 35164553›Full record

ArticlemBio2021

Replicative Aging Remodels the Cell Wall and Is Associated with Increased Intracellular Trafficking in Human Pathogenic Yeasts.

Vanessa K A Silva, Somanon Bhattacharya, Natalia Kronbauer Oliveira, Anne G Savitt, Daniel Zamith-Miranda, Joshua D Nosanchuk, Bettina C Fries

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Acetylation and accessibility ofCell surface (Amsterdam, Netherlands) · 2026
    Article
  3. Snooping helices: The elastic path finding algorithm of growing hyphae.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Article
  6. Peroxisomes regulate virulence and cell density sensing inbioRxiv : the preprint server for biology · 2025
    Article
  7. Is Cryptococcus neoformans a pleomorphic fungus?Current opinion in microbiology · 2024
    Review
  8. The pathobiology of human fungal infections.Nature reviews. Microbiology · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Antifungal Effect of Vitamin DJournal of fungi (Basel, Switzerland) · 2023
    Article
  13. Article
  14. A common vesicle proteome drives fungal biofilm development.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Vanessa K A Silva *Division of Infectious Diseases, Department of Medicine, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.ORCID 0000-0002-1778-5858
Somanon Bhattacharya *Division of Infectious Diseases, Department of Medicine, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.ORCID 0000-0002-8562-3877
Natalia Kronbauer OliveiraDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.ORCID 0000-0001-5381-0988
Anne G SavittDivision of Infectious Diseases, Department of Medicine, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.ORCID 0000-0002-5604-5393
Daniel Zamith-MirandaDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0001-7532-2432
Joshua D NosanchukDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.ORCID 0000-0001-9905-5754
Bettina C FriesDivision of Infectious Diseases, Department of Medicine, Stony Brook Universitygrid.36425.36, Stony Brook, New York, USA.
Stony Brook School · USAlbert Einstein College of Medicine · USStony Brook University · US

Funding

Investigation on Replicative aging in Cryptococcus neoformans populationsR01AI127704 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI FRIES, BETTINA · 2017 to 2021
$3.2M
Investigation on Replicative aging in Cryptococcus neoformans populationsR56AI127704 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI FRIES, BETTINA · 2023 to 2023
$555k
BLRD VA I01 BX003741NIAID NIH HHS R01 AI127704NIAID NIH HHS R56 AI127704
6 · The paper itself

Abstract

Replicative aging is an underexplored field of research in medical mycology. Cryptococcus neoformans (

Indexed as

CryptococcosisCryptococcus neoformansAgedAgingAntifungal AgentsCandida glabrataCell WallHumansAntifungal AgentsCandida glabratacell wallCryptococcus neoformansreplicative lifespanvesicle trafficking

Identifiers

PMID35164553
PMCPMC8844920
OpenAlexW4212881216

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.