Evidence map›Paper›PMID 35164361›Full record

ArticleMolecules (Basel, Switzerland)2022

Discovery of Novel Non-Oxime Reactivators Showing In Vivo Antidotal Efficiency for Sarin Poisoned Mice.

Zhao Wei, Xinlei Zhang, Huifang Nie, Lin Yao, Yanqin Liu, Zhibing Zheng, Qin Ouyang

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Zhao WeiDepartment of Medicinal Chemistry, School of Pharmacy, Air Force Medical University, Xi'an 300071, China.ORCID 0000-0003-1092-1690
Xinlei ZhangDepartment of Medicinal Chemistry, School of Pharmacy, Air Force Medical University, Xi'an 300071, China.
Huifang NieDepartment of Medicinal Chemistry, School of Pharmacy, Air Force Medical University, Xi'an 300071, China.
Lin YaoDepartment of Medicinal Chemistry, School of Pharmacy, Air Force Medical University, Xi'an 300071, China.
Yanqin LiuInstitute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China.
Zhibing ZhengInstitute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China.
Qin OuyangDepartment of Medicinal Chemistry, School of Pharmacy, Third Military Medical University, Chongqing 400038, China.
Air Force Engineering University · CNAcademy of Military Medical Sciences · CNArmy Medical University · CN

Funding

National Natural Science Foundation of China 81703413
6 · The paper itself

Abstract

A family of novel efficient non-oxime compounds exhibited promising reactivation efficacy for VX and sarin inhibited human acetylcholinesterase was discovered. It was found that aromatic groups coupled to Mannich phenols and the introduction of imidazole to the ortho position of phenols would dramatically enhance reactivation efficiency. Moreover, the in vivo experiment was conducted, and the results demonstrated that Mannich phenol

Indexed as

AcetylcholinesteraseAnimalsAntidotesChemical Warfare AgentsCholinesterase ReactivatorsHumansMiceNeurotoxicity SyndromesOximesPyridinium CompoundsSarinAcetylcholinesteraseAntidotesChemical Warfare AgentsCholinesterase ReactivatorsOximesPyridinium CompoundsSarinacetylcholinesteraseMannich phenolnon-oximesorganophosphatereactivators

Identifiers

PMID35164361
PMCPMC8840479
OpenAlexW4210843291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.