Evidence map›Paper›PMID 35164325›Full record

ArticleMolecules (Basel, Switzerland)2022

Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors:

Galina F Makhaeva, Nadezhda V Kovaleva, Natalia P Boltneva, Elena V Rudakova, Sofya V Lushchekina, Tatiana Yu Astakhova, Igor V Serkov, Alexey N Proshin, Eugene V Radchenko, Vladimir A Palyulin and 4 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  6. Molecules (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Galina F MakhaevaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-8136-6906
Nadezhda V KovalevaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-4990-5068
Natalia P BoltnevaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-7171-8832
Elena V RudakovaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-4600-7799
Sofya V LushchekinaInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-6922-020X
Tatiana Yu AstakhovaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334 Moscow, Russia.ORCID 0000-0002-3034-9698
Igor V SerkovInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.
Alexey N ProshinInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0002-3970-5767
Eugene V RadchenkoDepartment of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0002-2091-7022
Vladimir A PalyulinDepartment of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.ORCID 0000-0001-8792-8386
Jan KorabecnyBiomedical Research Centre, University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czech Republic.ORCID 0000-0001-6977-7596
Ondrej SoukupBiomedical Research Centre, University Hospital Hradec Kralove, 500 05 Hradec Kralove, Czech Republic.
Sergey O BachurinInstitute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Russia.ORCID 0000-0003-3637-818X
Rudy J RichardsonDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-2028-5723
Institute of Physiologically Active Compounds · RUInstitute of Biochemical Physics NM Emanuel · RULomonosov Moscow State University · RUUniversity Hospital Hradec Králové · CZUniversity of Michigan · US

Funding

Alternatives Research and Development Foundation N/ACzech Science Foundation 20-29633JIPAC RAS State Targets Project 0090-2019-0005Mcubed N/ARussian Foundation for Basic Research 19-53-26016_a
6 · The paper itself

Abstract

Using two ways of functionalizing amiridine-acylation with chloroacetic acid chloride and reaction with thiophosgene-we have synthesized new homobivalent bis-amiridines joined by two different spacers-bis-

Indexed as

AcetylcholinesteraseAlzheimer DiseaseAminoquinolinesAntioxidantsButyrylcholinesteraseCholinesterase InhibitorsGPI-Linked ProteinsHumansKineticsModels, MolecularMolecular Docking SimulationMolecular StructureNeuroprotective AgentsStructure-Activity RelationshipAcetylcholinesteraseACHE protein, humanAminoquinolinesamiridineAntioxidantsBCHE protein, humanButyrylcholinesteraseCholinesterase InhibitorsGPI-Linked ProteinsNeuroprotective Agentsacetylcholinesterase (AChE)ADMETAlzheimer’s disease (AD)amiridineantioxidantsbutyrylcholinesterase (BChE)N-acylamideneuroprotectionthioureaβ-amyloid (Aβ42)

Identifiers

PMID35164325
PMCPMC8839189
OpenAlexW4213363627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.