Evidence map›Paper›PMID 35164240›Full record

ReviewMolecules (Basel, Switzerland)2022

Analytical Techniques for Phytocannabinoid Profiling of Cannabis and Cannabis-Based Products-A Comprehensive Review.

Gjoshe Stefkov, Ivana Cvetkovikj Karanfilova, Veronika Stoilkovska Gjorgievska, Ana Trajkovska, Nikola Geskovski, Marija Karapandzova, Svetlana Kulevanova

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Repellent, Lethal Activity, and Synergism ofPlants (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Chemical profiling ofHeliyon · 2023
    Article
  16. Recent Research onMolecules (Basel, Switzerland) · 2023
    Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gjoshe StefkovInstitute of Pharmacognosy, Faculty of Pharmacy, Ss. Cyril and Methodius University, Bul. Majka Tereza 47, 1000 Skopje, North Macedonia.
Ivana Cvetkovikj KaranfilovaInstitute of Pharmacognosy, Faculty of Pharmacy, Ss. Cyril and Methodius University, Bul. Majka Tereza 47, 1000 Skopje, North Macedonia.ORCID 0000-0002-4248-140X
Veronika Stoilkovska GjorgievskaInstitute of Pharmacognosy, Faculty of Pharmacy, Ss. Cyril and Methodius University, Bul. Majka Tereza 47, 1000 Skopje, North Macedonia.ORCID 0000-0001-8656-1316
Ana TrajkovskaInstitute of Pharmacognosy, Faculty of Pharmacy, Ss. Cyril and Methodius University, Bul. Majka Tereza 47, 1000 Skopje, North Macedonia.
Nikola GeskovskiInstitute of Pharmaceutical Technology, Faculty of Pharmacy, Ss. Cyril and Methodius University, Bul. Majka Tereza 47, 1000 Skopje, North Macedonia.ORCID 0000-0002-2073-5632
Marija KarapandzovaInstitute of Pharmacognosy, Faculty of Pharmacy, Ss. Cyril and Methodius University, Bul. Majka Tereza 47, 1000 Skopje, North Macedonia.ORCID 0000-0002-4596-081X
Svetlana KulevanovaInstitute of Pharmacognosy, Faculty of Pharmacy, Ss. Cyril and Methodius University, Bul. Majka Tereza 47, 1000 Skopje, North Macedonia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cannabis is gaining increasing attention due to the high pharmacological potential and updated legislation authorizing multiple uses. The development of time- and cost-efficient analytical methods is of crucial importance for phytocannabinoid profiling. This review aims to capture the versatility of analytical methods for phytocannabinoid profiling of cannabis and cannabis-based products in the past four decades (1980-2021). The thorough overview of more than 220 scientific papers reporting different analytical techniques for phytocannabinoid profiling points out their respective advantages and drawbacks in terms of their complexity, duration, selectivity, sensitivity and robustness for their specific application, along with the most widely used sample preparation strategies. In particular, chromatographic and spectroscopic methods, are presented and discussed. Acquired knowledge of phytocannabinoid profile became extremely relevant and further enhanced chemotaxonomic classification, cultivation set-ups examination, association of medical and adverse health effects with potency and/or interplay of certain phytocannabinoids and other active constituents, quality control (QC), and stability studies, as well as development and harmonization of global quality standards. Further improvement in phytocannabinoid profiling should be focused on untargeted analysis using orthogonal analytical methods, which, joined with cheminformatics approaches for compound identification and MSLs, would lead to the identification of a multitude of new phytocannabinoids.

Indexed as

AnimalsCannabinoidsCannabisChromatography, GasChromatography, LiquidHumansMass SpectrometryPhytochemicalsQuality ControlSpectrophotometry, UltravioletCannabinoidsPhytochemicalsanalysisCannabis sativaquality controlsample preparation

Identifiers

PMID35164240
PMCPMC8838193

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.