Synthesis of DPIE [2-(1,2-Diphenyl-1

Jeongah Lim, Jihyoun Seong, Seunggon Jung, Tae-Hoon Lee, Eunae Kim, Sunwoo Lee

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.1field-weighted citation impact, top 63% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jeongah LimDepartment of Chemistry, Chonnam National University, Gwangju 61186, Korea.

Jihyoun SeongDepartment of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.

Seunggon JungDepartment of Oral & Maxillofacial Surgery, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.

Tae-Hoon LeeDepartment of Oral Biochemistry, Dental Science Research Institute, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.

Eunae KimCollege of Pharmacy, Chosun University, Gwangju 61452, Korea.ORCID 0000-0001-8538-7336

Sunwoo LeeDepartment of Chemistry, Chonnam National University, Gwangju 61186, Korea.

Chonnam National University · KRChosun University · KR

Funding

Commercializations Promotion Agency for R&D Outcomes(COMPA) 2021C200National Research Foundation of Korea NRF-2021R1A2C1005169

6 · The paper itself

Abstract

Interleukin-1 beta (IL-1β) has diverse physiological functions and plays important roles in health and disease. In this report, we focus on its function in the production of pro-inflammatory cytokines, including IL-6 and IL-8, which are implicated in several autoimmune diseases and host defense against infection. IL-1β activity is markedly dependent on the binding affinity toward IL-1 receptors (IL-1Rs). Several studies have been conducted to identify suitable small molecules that can modulate the interactions between 1L-1β and 1L-1R1. Based on our previous report, where DPIE [2-(1,2-Diphenyl-1

Indexed as

Anti-Inflammatory AgentsCells, CulturedCytokinesFibroblastsHumansIndolesInflammationInflammation MediatorsInterleukin-1betaPhenethylaminesAnti-Inflammatory AgentsCytokinesIL1B protein, humanIndolesInflammation MediatorsInterleukin-1betaPhenethylaminesDPIE derivativeIL-1IL-1R1pro-inflammatory cytokine

Identifiers

PMID35164164

DOI10.3390/molecules27030899

PMCPMC8840366

OpenAlexW4213150780

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.