Evidence map›Paper›PMID 35164106›Full record

ArticleMolecules (Basel, Switzerland)2022

One-Pot Synthesis of Novel 2-Imino-5-Arylidine-Thiazolidine Analogues and Evaluation of Their Anti-Proliferative Activity against MCF7 Breast Cancer Cell Line.

Marian N Aziz, Arzoo Patel, Amany Iskander, Avisankar Chini, Delphine Gout, Subhrangsu S Mandal, Carl J Lovely

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Copper-Catalyzed One-Pot Synthesis of Thiazolidin-2-imines.The Journal of organic chemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marian N AzizDepartment of Chemistry and Biochemistry, University of Texas-Arlington, Arlington, TX 76019-0065, USA.
Arzoo PatelDepartment of Chemistry and Biochemistry, University of Texas-Arlington, Arlington, TX 76019-0065, USA.
Amany IskanderDepartment of Chemistry and Biochemistry, University of Texas-Arlington, Arlington, TX 76019-0065, USA.
Avisankar ChiniDepartment of Chemistry and Biochemistry, University of Texas-Arlington, Arlington, TX 76019-0065, USA.
Delphine GoutDepartment of Chemistry and Biochemistry, University of Texas-Arlington, Arlington, TX 76019-0065, USA.
Subhrangsu S MandalDepartment of Chemistry and Biochemistry, University of Texas-Arlington, Arlington, TX 76019-0065, USA.
Carl J LovelyDepartment of Chemistry and Biochemistry, University of Texas-Arlington, Arlington, TX 76019-0065, USA.ORCID 0000-0001-7012-2001

Funding

Histone methylase MLL2 in regulation of SR-BI expression and plasma cholesterolR15HL142032 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI MANDAL, SUBHRANGSU S · 2018 to 2018
$439k
NHLBI NIH HHS R15 HL142032
6 · The paper itself

Abstract

An efficient surface-mediated synthetic method to facilitate access to a novel class of thiazolidines is described. The rationale behind the design of the targeted thiazolidines was to prepare stable thiazolidine analogues and evaluate their anti-proliferative activity against a breast cancer cell line (MCF7). Most of the synthesized analogues exhibited increased potency ranging from 2-15-fold higher compared to the standard reference, cisplatin. The most active thiazolidines contain a halogenated or electron withdrawing group attached to the

Indexed as

Antineoplastic AgentsThiazolidinesBreast NeoplasmsCell ProliferationFemaleHumansMCF-7 CellsStructure-Activity RelationshipAntineoplastic AgentsThiazolidinescytotoxicityhydrothiolationpropargyl aminesurface-mediated cyclizationX-ray

Identifiers

PMID35164106
PMCPMC8840064

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.