Evidence map›Paper›PMID 35164094›Full record

ArticleMolecules (Basel, Switzerland)2022

Iboga Inspired

Mariana Pazos, Estefania Dibello, Juan Manuel Mesa, Dalibor Sames, Marcelo Alberto Comini, Gustavo Seoane, Ignacio Carrera

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Mariana PazosLaboratorio de Síntesis Orgánica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, General Flores 2124, Montevideo 11800, Uruguay.
Estefania DibelloLaboratorio de Síntesis Orgánica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, General Flores 2124, Montevideo 11800, Uruguay.
Juan Manuel MesaLaboratorio de Síntesis Orgánica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, General Flores 2124, Montevideo 11800, Uruguay.
Dalibor SamesDepartment of Chemistry, Columbia University, New York, NY 10027, USA.
Marcelo Alberto CominiGroup Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Mataojo 2020, Montevideo 11400, Uruguay.ORCID 0000-0001-5000-1333
Gustavo SeoaneLaboratorio de Síntesis Orgánica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, General Flores 2124, Montevideo 11800, Uruguay.
Ignacio CarreraLaboratorio de Síntesis Orgánica, Departamento de Química Orgánica, Facultad de Química, Universidad de la República, General Flores 2124, Montevideo 11800, Uruguay.ORCID 0000-0002-6053-3162
Universidad de la República de Uruguay · UYColumbia University · USInstitut Pasteur de Montevideo · UY

Funding

Agencia Nacional de Investigación e Innovación Fondo María Viñas FMV_1_2014_1_103488)Comisión Sectorial de Investigación Científica (Universidad de la Republica) CSIC-Grupos I+D 1063Programa de Desarrollo de las Ciencias Básicas PEDECIBA
6 · The paper itself

Abstract

The first stage of the drug discovery process involves the identification of small compounds with biological activity. Iboga alkaloids are monoterpene indole alkaloids (MIAs) containing a fused isoquinuclidine-tetrahydroazepine ring. Both the natural products and the iboga-inspired synthetic analogs have shown a wide variety of biological activities. Herein, we describe the chemoenzymatic preparation of a small library of novel

Indexed as

AlkaloidsAntiprotozoal AgentsAnimalsCell Line, TumorGlial Cell Line-Derived Neurotrophic FactorMiceRatsTabernaemontanaTrypanosoma brucei bruceiTrypanosomiasis, AfricanAlkaloidsAntiprotozoal AgentsGlial Cell Line-Derived Neurotrophic Factoranti-trypanosomaGDNFiboga alkaloidimino Diels–Alderisoquinuclidinetoluenedioxigenase

Identifiers

PMID35164094
PMCPMC8839081
OpenAlexW4210347461

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.