Evidence map›Paper›PMID 35164091›Full record

ArticleMolecules (Basel, Switzerland)2022

Design, Synthesis and Molecular Docking Study of Novel 3-Phenyl-β-Alanine-Based Oxadiazole Analogues as Potent Carbonic Anhydrase II Inhibitors.

Kashif Rafiq, Najeeb Ur Rehman, Sobia Ahsan Halim, Majid Khan, Ajmal Khan, Ahmed Al-Harrasi

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Kashif RafiqNatural and Medical Sciences Research Center, University of Nizwa, P.O Box 33, Birkat Al Mauz, Nizwa 616, Oman.
Najeeb Ur RehmanNatural and Medical Sciences Research Center, University of Nizwa, P.O Box 33, Birkat Al Mauz, Nizwa 616, Oman.ORCID 0000-0002-1563-225X
Sobia Ahsan HalimNatural and Medical Sciences Research Center, University of Nizwa, P.O Box 33, Birkat Al Mauz, Nizwa 616, Oman.
Majid KhanNatural and Medical Sciences Research Center, University of Nizwa, P.O Box 33, Birkat Al Mauz, Nizwa 616, Oman.ORCID 0000-0002-9287-2046
Ajmal KhanNatural and Medical Sciences Research Center, University of Nizwa, P.O Box 33, Birkat Al Mauz, Nizwa 616, Oman.
Ahmed Al-HarrasiNatural and Medical Sciences Research Center, University of Nizwa, P.O Box 33, Birkat Al Mauz, Nizwa 616, Oman.ORCID 0000-0002-0815-5942
University of Nizwa · OMAbdul Wali Khan University Mardan · PKUniversity of Karachi · PK

Funding

The Research Council BFP/RGP/CBS/21/002
6 · The paper itself

Abstract

Carbonic anhydrase-II (CA-II) is strongly related with gastric, glaucoma, tumors, malignant brain, renal and pancreatic carcinomas and is mainly involved in the regulation of the bicarbonate concentration in the eyes. With an aim to develop novel heterocyclic hybrids as potent enzyme inhibitors, we synthesized a series of twelve novel 3-phenyl-β-alanine 1,3,4-oxadiazole hybrids (

Indexed as

AlanineCarbonic Anhydrase IICarbonic Anhydrase InhibitorsCatalytic DomainDrug DesignHumansMolecular Docking SimulationOxadiazolesAlanineCarbonic Anhydrase IICarbonic Anhydrase InhibitorsOxadiazoles3-phenyl-β-alanine 1,3,4-oxadiazole hybridscarbonic anhydrase-IImolecular dockingstructure-activity relationshipα-glucosidase

Identifiers

PMID35164091
PMCPMC8838037
OpenAlexW4210820767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.