Evidence map›Paper›PMID 35164061›Full record

ArticleMolecules (Basel, Switzerland)2022

Mechanistic Insight into Binding of Huperzine A with Human Serum Albumin: Computational and Spectroscopic Approaches.

Anas Shamsi, Moyad Shahwan, Mohd Shahnawaz Khan, Fahad A Alhumaydhi, Suliman A Alsagaby, Waleed Al Abdulmonem, Bekhzod Abdullaev, Dharmendra Kumar Yadav

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 5 countries.

Anas ShamsiCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.ORCID 0000-0001-7055-7056
Moyad ShahwanCentre of Medical and Bio-Allied Health Sciences Research, Ajman University, Ajman P.O. Box 346, United Arab Emirates.ORCID 0000-0001-8367-4841
Mohd Shahnawaz KhanDepartment of Biochemistry, College of Sciences, King Saud University, Riyadh 11451, Saudi Arabia.
Fahad A AlhumaydhiDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraidah 52571, Saudi Arabia.ORCID 0000-0002-0151-8309
Suliman A AlsagabyDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah 11932, Saudi Arabia.ORCID 0000-0002-2242-5638
Waleed Al AbdulmonemDepartment of Pathology, College of Medicine, Qassim University, Buraidah 51452, Saudi Arabia.ORCID 0000-0003-2984-9262
Bekhzod AbdullaevScientific Department, Akfa University, Tashkent 100022, Uzbekistan.ORCID 0000-0001-7798-7382
Dharmendra Kumar YadavCollege of Pharmacy, Gachon University of Medicine and Science, Hambakmoeiro, Yeonsu-gu, Incheon 21924, Korea.ORCID 0000-0003-1102-1993
Ajman University · AEQassim University · SACentral Asian University · UZGachon University · KRKing Saud University · SAMajmaah University · SA

Funding

King Saud University RSP-2021/352
6 · The paper itself

Abstract

Human serum albumin (HSA) is the most abundant protein in plasma synthesized by the liver and the main modulator of fluid distribution between body compartments. It has an amazing capacity to bind with multiple ligands, offering a store and transporter for various endogenous and exogenous compounds. Huperzine A (HpzA) is a natural sesquiterpene alkaloid found in

Indexed as

AlkaloidsHumansHydrogen BondingMolecular Docking SimulationMolecular Dynamics SimulationNeuroprotective AgentsPrincipal Component AnalysisProtein BindingSerum Albumin, HumanSesquiterpenesSpectrometry, FluorescenceAlkaloidshuperzine ANeuroprotective AgentsSerum Albumin, HumanSesquiterpenesdrug–protein interactionsfluorescence spectroscopyhuman serum albuminHuperzine Amolecular dynamics simulationneurodegenerative disorders

Identifiers

PMID35164061
PMCPMC8839580
OpenAlexW4210249652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.