Evidence map›Paper›PMID 35164041›Full record

ReviewMolecules (Basel, Switzerland)2022

Recent Analytical Approaches for the Study of Bioavailability and Metabolism of Bioactive Phenolic Compounds.

Álvaro Fernández-Ochoa, María de la Luz Cádiz-Gurrea, Patricia Fernández-Moreno, Alejandro Rojas-García, David Arráez-Román, Antonio Segura-Carretero

Registry-linked trialAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05774613 (Bioavailability of Antioxidant Compounds and Effect on Markers of Inflammation by Ingestion of a Hibiscus Sabdariffa Beverage With Glicemic and Insulinemic Response), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05774613 naunknown statusnot on this map

Bioavailability of Antioxidant Compounds and Effect on Markers of Inflammation by Ingestion of a Hibiscus Sabdariffa Beverage With Glicemic and Insulinemic Response

TypeinterventionalSponsorInstituto Tecnológico y de Estudios Superiores de OccidenteRan2021 to 2023Enrolled12ConditionsMarkers of Inflammation, Hyperglycemia, Postprandial, HyperinsulinismArmsEffect of a Hibiscus sabdariffa beverage
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. PlantInternational journal of molecular sciences · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Álvaro Fernández-OchoaMax Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.ORCID 0000-0001-5547-3209
María de la Luz Cádiz-GurreaDepartment of Analytical Chemistry, Faculty of Sciences, University of Granada, Fuentenueva s/n, E-18071 Granada, Spain.ORCID 0000-0002-2613-4889
Patricia Fernández-MorenoDepartment of Analytical Chemistry, Faculty of Sciences, University of Granada, Fuentenueva s/n, E-18071 Granada, Spain.
Alejandro Rojas-GarcíaDepartment of Analytical Chemistry, Faculty of Sciences, University of Granada, Fuentenueva s/n, E-18071 Granada, Spain.ORCID 0000-0002-7020-2017
David Arráez-RománDepartment of Analytical Chemistry, Faculty of Sciences, University of Granada, Fuentenueva s/n, E-18071 Granada, Spain.ORCID 0000-0003-1267-6676
Antonio Segura-CarreteroDepartment of Analytical Chemistry, Faculty of Sciences, University of Granada, Fuentenueva s/n, E-18071 Granada, Spain.

Funding

Ministry of Science, Innovation and Universities RTI2018-096724-B-C22Regional Government of Andalusia A-AGR-226-UGR20
6 · The paper itself

Abstract

The study of the bioavailability of bioactive compounds is a fundamental step for the development of applications based on them, such as nutraceuticals, functional foods or cosmeceuticals. It is well-known that these compounds can undergo metabolic reactions before reaching therapeutic targets, which may also affect their bioactivity and possible applications. All recent studies that have focused on bioavailability and metabolism of phenolic and terpenoid compounds have been developed because of the advances in analytical chemistry and metabolomics approaches. The purpose of this review is to show the role of analytical chemistry and metabolomics in this field of knowledge. In this context, the different steps of the analytical chemistry workflow (design study, sample treatment, analytical techniques and data processing) applied in bioavailability and metabolism in vivo studies are detailed, as well as the most relevant results obtained from them.

Indexed as

Biological AvailabilityFunctional FoodGas Chromatography-Mass SpectrometryMetabolomicsPhenolsPlant ExtractsPhenolsPlant Extractsanalytical chemistrybioactive compoundsbioavailabilitychromatographymass spectrometrymetabolismmetabolomicsphenolic compoundsphytochemicalsuntargeted

Identifiers

PMID35164041
PMCPMC8838714

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.