ArticleCell and tissue research1986
Cell shape and motility of oligodendrocytes cultured without neurons.
Article in Cell and tissue research, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- An activity-modulated transport route across myelin (TRAM) for motor-driven organelle transfer in oligodendrocytes.Nature neuroscience · 2026Article
- The Many Lives of an Oligodendrocyte Precursor Cell.Annual review of neuroscience · 2025Review
- Protocadherin 15 suppresses oligodendrocyte progenitor cell proliferation and promotes motility through distinct signalling pathways.Communications biology · 2022Article
- Review
- Evolvability of the actin cytoskeleton in oligodendrocytes during central nervous system development and aging.Cellular and molecular life sciences : CMLS · 2019Review
- Review
- On Myelinated Axon Plasticity and Neuronal Circuit Formation and Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Review
- Article
- CNS myelination requires cytoplasmic dynein function.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- CaMKIIβ regulates oligodendrocyte maturation and CNS myelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Myosin II is a negative regulator of oligodendrocyte morphological differentiation.Journal of neuroscience research · 2012Article
- Lysophosphatidic acid can support the formation of membranous structures and an increase in MBP mRNA levels in differentiating oligodendrocytes.Neurochemical research · 2009Article
- Myosin II has distinct functions in PNS and CNS myelin sheath formation.The Journal of cell biology · 2008Article
- Phosphodiesterase-Ialpha/autotaxin's MORFO domain regulates oligodendroglial process network formation and focal adhesion organization.Molecular and cellular neurosciences · 2008Article
- Myosin Va controls oligodendrocyte morphogenesis and myelination.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Identification of a novel oligodendrocyte cell adhesion protein using gene expression profiling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Rho kinase regulates schwann cell myelination and formation of associated axonal domains.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Myosin light chain kinase inhibitors induce retraction of mature oligodendrocyte processes.Neurochemical research · 2002Article
- Myelin biogenesis: vesicle transport in oligodendrocytes.Neurochemical research · 2002Review
- Microtubule organization and stability in the oligodendrocyte.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), were cultured from newborn rat brain and optic nerve to study how they differentiate in vitro in the absence of neurons. By use of galactocerebroside (GC) as a reference marker, the development of the cell phenotype was studied with video-enhanced differential interference contrast microscopy, immunofluorescence and electron microscopy. After a few days in culture, oligodendrocytes extend 5 to 10 main processes that are very rich in microtubules, but they did not stain with a monoclonal antibody reacting with all known classes of intermediate filaments. The number of processes can vary with the substrate on which the cells are grown; fewer processes form on laminin than on polylysine coated glass. Oligodendrocytes, in a fashion similar to that of neurons appear to keep their body immobile while the long processes grow. However, while neurons display motile activities mostly at the end of the cell processes called growth cones, the oligodendrocytes display motile, actin rich filopodia and lamellipodia along the entire length of all processes. The outgrowth of motile processes from oligodendrocytes sometimes occurs preferentially towards neighboring astrocytes. Oligodendrocyte processes display intense bidirectional movement of cytoplasmic organelles. Movement of surface components also occurs since GC molecules cross-linked by antibodies move from the processes towards the cell body. Thus, oligodendrocytes cultured without neurons develop on schedule a complex phenotype similar to their in vivo counterpart. In addition, their processes are capable of specific motile activities which may function in vivo to find the target axon and to transport myelin membrane components at the site of myelin assembly.
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Registered trials
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