Evidence map›Paper›PMID 35164002›Full record

ArticleMolecules (Basel, Switzerland)2022

General Method to Increase Carboxylic Acid Content on Nanodiamonds.

Ganesh Shenoy, Jessica Ettedgui, Chandrasekhar Mushti, Jennifer Hong, Kelly Lane, Burchelle Blackman, Hak-Sung Jung, Yasuharu Takagi, Yeonee Seol, Martin Brechbiel and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ganesh ShenoyLaboratory of Single Molecule Biophysics, National Heart Lung and Blood Institute, National Institutes of Health, Building 50, Room 2134, Bethesda, MD 20892, USA.
Jessica EttedguiChemistry and Synthesis Center, National Heart Lung and Blood Institute, National Institutes of Health, Building B, Room 3040, 9800 Medical Center Drive, Rockville, MD 20850, USA.
Chandrasekhar MushtiChemistry and Synthesis Center, National Heart Lung and Blood Institute, National Institutes of Health, Building B, Room 3040, 9800 Medical Center Drive, Rockville, MD 20850, USA.
Jennifer HongLaboratory of Single Molecule Biophysics, National Heart Lung and Blood Institute, National Institutes of Health, Building 50, Room 2134, Bethesda, MD 20892, USA.
Kelly LaneChemistry and Synthesis Center, National Heart Lung and Blood Institute, National Institutes of Health, Building B, Room 3040, 9800 Medical Center Drive, Rockville, MD 20850, USA.
Burchelle BlackmanChemistry and Synthesis Center, National Heart Lung and Blood Institute, National Institutes of Health, Building B, Room 3040, 9800 Medical Center Drive, Rockville, MD 20850, USA.
Hak-Sung JungLaboratory of Single Molecule Biophysics, National Heart Lung and Blood Institute, National Institutes of Health, Building 50, Room 2134, Bethesda, MD 20892, USA.
Yasuharu TakagiLaboratory of Single Molecule Biophysics, National Heart Lung and Blood Institute, National Institutes of Health, Building 50, Room 2134, Bethesda, MD 20892, USA.
Yeonee SeolLaboratory of Single Molecule Biophysics, National Heart Lung and Blood Institute, National Institutes of Health, Building 50, Room 2134, Bethesda, MD 20892, USA.
Martin BrechbielRadiation Oncology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room B3B69, Bethesda, MD 20892, USA.
Rolf E SwensonChemistry and Synthesis Center, National Heart Lung and Blood Institute, National Institutes of Health, Building B, Room 3040, 9800 Medical Center Drive, Rockville, MD 20850, USA.
Keir C NeumanLaboratory of Single Molecule Biophysics, National Heart Lung and Blood Institute, National Institutes of Health, Building 50, Room 2134, Bethesda, MD 20892, USA.ORCID 0000-0002-0863-5671
National Institutes of Health · US

Funding

Imaging Probe Development CenterZICHL005090 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SWENSON, ROLF · 2011 to 2025
$22.2M
Development and characterization of optical imaging probesZIAHL006087 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI NEUMAN, KEIR · 2010 to 2024
$3.9M
National Heart Lung and Blood Institute 1ZIAHL006087-05
6 · The paper itself

Abstract

Carboxylic acid is a commonly utilized functional group for covalent surface conjugation of carbon nanoparticles that is typically generated by acid oxidation. However, acid oxidation generates additional oxygen containing groups, including epoxides, ketones, aldehydes, lactones, and alcohols. We present a method to specifically enrich the carboxylic acid content on fluorescent nanodiamond (FND) surfaces. Lithium aluminum hydride is used to reduce oxygen containing surface groups to alcohols. The alcohols are then converted to carboxylic acids through a rhodium (II) acetate catalyzed carbene insertion reaction with

Indexed as

fluorescent nanodiamondfunctionalizationoptical trappingrhodium catalysisTIRF

Identifiers

PMID35164002
PMCPMC8838522
OpenAlexW4207042128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.