Evidence map›Paper›PMID 35163957›Full record

ArticleMolecules (Basel, Switzerland)2022

In Vitro and In Silico Study of Analogs of Plant Product Plastoquinone to Be Effective in Colorectal Cancer Treatment.

Halilibrahim Ciftci, Belgin Sever, Firdevs Ocak, Nilüfer Bayrak, Mahmut Yıldız, Hatice Yıldırım, Hasan DeMirci, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Pharmaceuticals (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Halilibrahim CiftciDepartment of Drug Discovery, Science Farm Ltd., Kumamoto 862-0976, Japan.ORCID 0000-0002-9796-7669
Belgin SeverMedicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.ORCID 0000-0003-4847-9711
Firdevs OcakFaculty of Medicine, Kocaeli University, Kocaeli 41001, Turkey.
Nilüfer BayrakDepartment of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Istanbul 34320, Turkey.
Mahmut YıldızChemistry Department, Gebze Technical University, Kocaeli 41400, Turkey.
Hatice YıldırımDepartment of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpasa, Istanbul 34320, Turkey.
Hasan DeMirciDepartment of Molecular Biology and Genetics, Koc University, Istanbul 34450, Turkey.ORCID 0000-0002-9135-5397
Hiroshi TateishiMedicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
Masami OtsukaDepartment of Drug Discovery, Science Farm Ltd., Kumamoto 862-0976, Japan.
Mikako FujitaMedicinal and Biological Chemistry Science Farm Joint Research Laboratory, Faculty of Life Sciences, Kumamoto University, Kumamoto 862-0973, Japan.ORCID 0000-0001-6705-4052
Amaç Fatih TuYuNDepartment of Chemistry, Faculty of Science, Istanbul University, Istanbul 34126, Turkey.
Kumamoto University · JPIstanbul University-Cerrahpaşa · TRKoç University · TRAnadolu University · TRGebze Technical University · TRIstanbul University · TRKocaeli Üniversitesi · TR

Funding

The Scientific Research Projects Coordination Unit of Istanbul University-Cerrahpasa FBA-2017-24559TUBITAK 2236 CoCirculation2 12C063
6 · The paper itself

Abstract

Plants have paved the way for the attainment of molecules with a wide-range of biological activities. However, plant products occasionally show low biological activities and/or poor pharmacokinetic properties. In that case, development of their derivatives as drugs from the plant world has been actively performed. As plant products, plastoquinones (

Indexed as

Antineoplastic AgentsApoptosisCell Line, TumorCell ProliferationColorectal NeoplasmsComputer SimulationDose-Response Relationship, DrugDrug DesignDrug Screening Assays, AntitumorHumansMolecular Docking SimulationMolecular StructurePlastoquinoneStructure-Activity RelationshipAntineoplastic AgentsPlastoquinoneapoptosiscolorectal cancercytotoxicityDNA cleavagemolecular dockingpharmacokinetic propertiesplastoquinones

Identifiers

PMID35163957
PMCPMC8839215
OpenAlexW4207077393

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.