Evidence map›Paper›PMID 35163847›Full record

ArticleMolecules (Basel, Switzerland)2022

Antimicrobial Activity and DFT Studies of a Novel Set of Spiropyrrolidines Tethered with Thiochroman-4-one/Chroman-4-one Scaffolds.

Nourhène Chouchène, Amani Toumi, Sarra Boudriga, Hayet Edziri, Mansour Sobeh, Mohamed A O Abdelfattah, Moheddine Askri, Michael Knorr, Carsten Strohmann, Lukas Brieger and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 6 countries.

Nourhène ChouchèneLaboratory of Heterocyclic Chemistry Natural Product and Reactivity (LR11ES39), Department of Chemistry, Faculty of Science of Monastir, University of Monastir, Monastir 5019, Tunisia.
Amani ToumiLaboratory of Heterocyclic Chemistry Natural Product and Reactivity (LR11ES39), Department of Chemistry, Faculty of Science of Monastir, University of Monastir, Monastir 5019, Tunisia.
Sarra BoudrigaLaboratory of Heterocyclic Chemistry Natural Product and Reactivity (LR11ES39), Department of Chemistry, Faculty of Science of Monastir, University of Monastir, Monastir 5019, Tunisia.ORCID 0000-0002-4706-5181
Hayet EdziriLaboratoire des Maladies Transmissibles et des Substances Biologiquement Actives, Faculté de Pharmacie, Monastir 5000, Tunisia.
Mansour SobehAgroBioSciences Research, Mohammed VI Polytechnic University, Lot 660-Hay MoulayRachid, Ben Guerir 43150, Morocco.ORCID 0000-0002-2719-8534
Mohamed A O AbdelfattahCollege of Engineering and Technology, American University of the Middle East, Kuwait.
Moheddine AskriLaboratory of Heterocyclic Chemistry Natural Product and Reactivity (LR11ES39), Department of Chemistry, Faculty of Science of Monastir, University of Monastir, Monastir 5019, Tunisia.
Michael KnorrInstitut UTINAM-UMR CNRS 6213, Université Bourgogne Franche-Comté, 16 Route de Gray, 25030 Besançon, France.ORCID 0000-0002-5647-8084
Carsten StrohmannFaculty of Chemistry, Inorganic Chemistry, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany.ORCID 0000-0002-4787-2135
Lukas BriegerFaculty of Chemistry, Inorganic Chemistry, Technical University Dortmund, Otto-Hahn-Strasse 6, 44227 Dortmund, Germany.
Armand SolderaLaboratory of Physical Chemistry of Matter, Department of Chemistry, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
University of Monastir · TNTU Dortmund University · DEAmerican University of the Middle East · KWCentre National de la Recherche Scientifique · FRUniversité de Sherbrooke · CAUniversité Mohammed VI Polytechnique · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and oxindole/acenaphthylene-1,2-dione moieties were synthesized and characterized by spectroscopic techniques, as well as by three X-ray diffraction studies, corroborating the stereochemistry. Quantum chemical calculations studies, using the DFT approach, were performed to rationalize the stereochemical outcome. These

Indexed as

Anti-Bacterial AgentsAntifungal AgentsBacteriaChromansFungiMicrobial Sensitivity TestsMolecular Docking SimulationMolecular StructureOxindolesSpiro CompoundsStructure-Activity Relationship2-oxindoleAnti-Bacterial AgentsAntifungal AgentsChromansOxindolesSpiro Compounds[3+2] cycloadditionchroman-4-onecrystal structureDFTspiropyrrolidinethiochroman-4-one

Identifiers

PMID35163847
PMCPMC8839074
OpenAlexW4205361562

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.