Evidence map›Paper›PMID 35163819›Full record

ArticleInternational journal of molecular sciences2022

Exposure to b-LED Light While Exerting Antimicrobial Activity on Gram-Negative and -Positive Bacteria Promotes Transient EMT-like Changes and Growth Arrest in Keratinocytes.

Michela Terri, Nicoletta Mancianti, Flavia Trionfetti, Bruno Casciaro, Valeria de Turris, Giammarco Raponi, Giulio Bontempi, Claudia Montaldo, Alessandro Domenici, Paolo Menè and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Antimicrobial photodynamic activity of a BODIPY on an alternative preclinical model Galleria mellonella.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Michela TerriDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Nicoletta ManciantiRenal Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0001-7009-2367
Flavia TrionfettiDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Bruno CasciaroCenter for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia (IIT), 00161 Rome, Italy.ORCID 0000-0003-1295-1084
Valeria de TurrisCenter for Life Nano- & Neuro-Science, Istituto Italiano di Tecnologia (IIT), 00161 Rome, Italy.ORCID 0000-0003-0872-185X
Giammarco RaponiDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-9665-0811
Giulio BontempiDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Claudia MontaldoGene Expression Laboratory, National Institute for Infectious Diseases, Lazzaro Spallanzani IRCCS, 00161 Rome, Italy.
Alessandro DomeniciRenal Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, 00189 Rome, Italy.
Paolo MenèRenal Unit, Department of Clinical and Molecular Medicine, Sant'Andrea University Hospital, Sapienza University of Rome, 00189 Rome, Italy.ORCID 0000-0001-6395-6227
Maria Luisa MangoniDepartment of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-5991-5868
Raffaele StrippoliDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0003-3483-8381
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITSapienza University of Rome · ITItalian Institute of Technology · ITIstituto Pasteur · IT

Funding

Italian Ministry for Education, University and Research FISR 2020-Covid FISR2020IP_03366Italian Ministry for Health Ricerca CorrenteSapienza University of Rome RM11916B6A28725C
6 · The paper itself

Abstract

While blue LED (b-LED) light is increasingly being studied for its cytotoxic activity towards bacteria in therapy of skin-related infections, its effects on eukaryotic cells plasticity are less well characterized. Moreover, since different protocols are often used, comparing the effect of b-LED towards both microorganisms and epithelial surfaces may be difficult. The aim of this study was to analyze, in the same experimental setting, both the bactericidal activity and the effects on human keratinocytes. Exposure to b-LED induced an intense cytocidal activity against Gram-positive (i.e,

Indexed as

Antigens, CDCadherinsCell Cycle CheckpointsCell ProliferationCyclin D1Cyclin-Dependent Kinase Inhibitor p21Down SyndromeEpithelial-Mesenchymal TransitionGene Expression RegulationHaCaT CellsHumansKeratinocytesLightMicrobial ViabilityPseudomonas aeruginosaSnail Family Transcription FactorsAntigens, CDCadherinsCCND1 protein, humanCDH1 protein, humanCDKN1A protein, humanCyclin D1Cyclin-Dependent Kinase Inhibitor p21SNAI1 protein, humanSnail Family Transcription Factorsb-led lightEMTgenotoxic damageskin infections

Identifiers

PMID35163819
PMCPMC8837184
OpenAlexW4211187837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.