Evidence map›Paper›PMID 35163794›Full record

ArticleInternational journal of molecular sciences2022

The Antibacterial Effect of PEGylated Carbosilane Dendrimers on

Sara Quintana-Sanchez, Natalia Gómez-Casanova, Javier Sánchez-Nieves, Rafael Gómez, Jarosław Rachuna, Sławomir Wąsik, Jacek Semaniak, Barbara Maciejewska, Zuzanna Drulis-Kawa, Karol Ciepluch and 2 more

Open access · goldAbstract readComparative Study
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Inhibition ofPharmaceutics · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Sara Quintana-SanchezDepartment of Organic and Inorganic Chemistry, Research Institute in Chemistry "Andrés M. del Río" (IQAR), University of Alcalá, 28871 Alcalá de Henares, Spain.
Natalia Gómez-CasanovaDepartment of Biomedicine and Biotechnology, Faculty of Pharmacy, University of Alcalá, 28871 Alcalá de Henares, Spain.ORCID 0000-0002-6983-1895
Javier Sánchez-NievesDepartment of Organic and Inorganic Chemistry, Research Institute in Chemistry "Andrés M. del Río" (IQAR), University of Alcalá, 28871 Alcalá de Henares, Spain.ORCID 0000-0003-0410-2285
Rafael GómezDepartment of Organic and Inorganic Chemistry, Research Institute in Chemistry "Andrés M. del Río" (IQAR), University of Alcalá, 28871 Alcalá de Henares, Spain.ORCID 0000-0001-6448-2414
Jarosław RachunaDivision of Medical Biology, Jan Kochanowski University, 25-406 Kielce, Poland.ORCID 0000-0002-0044-5419
Sławomir WąsikInstitute of Physics, Jan Kochanowski University, 25-406 Kielce, Poland.ORCID 0000-0003-0107-4493
Jacek SemaniakInstitute of Physics, Jan Kochanowski University, 25-406 Kielce, Poland.
Barbara MaciejewskaDepartment of Pathogen Biology and Immunology, University of Wroclaw, 51-148 Wroclaw, Poland.
Zuzanna Drulis-KawaDepartment of Pathogen Biology and Immunology, University of Wroclaw, 51-148 Wroclaw, Poland.ORCID 0000-0002-4733-4660
Karol CiepluchDivision of Medical Biology, Jan Kochanowski University, 25-406 Kielce, Poland.
F Javier de la MataDepartment of Organic and Inorganic Chemistry, Research Institute in Chemistry "Andrés M. del Río" (IQAR), University of Alcalá, 28871 Alcalá de Henares, Spain.ORCID 0000-0003-0418-3935
Michał ArabskiDivision of Medical Biology, Jan Kochanowski University, 25-406 Kielce, Poland.ORCID 0000-0002-9712-9286
Jan Kochanowski University · PLUniversidad de Alcalá · ESUniversity of Wrocław · PL

Funding

EPU-INV/2020/014 CAM, UAHIMMUNOTHERCAN CM B2017/BMD-3733 (CAM, Spain)PID2020-112924RB-I00 (MINECO, Spain), Consortiums NANODENDMED II-CM B2017/BMD-3703Polish National Science Centre 2017/27/B/NZ6/00199
6 · The paper itself

Abstract

The search for new microbicide compounds is of an urgent need, especially against difficult-to-eradicate biofilm-forming bacteria. One attractive option is the application of cationic multivalent dendrimers as antibacterials and also as carriers of active molecules. These compounds require an adequate hydrophilic/hydrophobic structural balance to maximize the effect. Herein, we evaluated the antimicrobial activity of cationic carbosilane (CBS) dendrimers unmodified or modified with polyethylene glycol (PEG) units, against planktonic and biofilm-forming

Indexed as

Anti-Bacterial AgentsBacteriophagesBiofilmsDendrimersDrug CompoundingDrug SynergismEndopeptidasesInterferometryMicrobial Sensitivity TestsMicrobial ViabilityMicroscopy, FluorescencePlanktonPolyethylene GlycolsPseudomonas aeruginosaSilanesAnti-Bacterial AgentscarbosilaneDendrimersendolysinEndopeptidasesPolyethylene GlycolsSilanesbacteriophagesbiofilmcarbosilane dendrimersendolysinlaser interferometrypolyethylene glycolPseudomonas aeruginosa

Identifiers

PMID35163794
PMCPMC8836974
OpenAlexW4210886334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.