ReviewInternational journal of molecular sciences2022
Inherited Thrombophilia in the Era of Direct Oral Anticoagulants.
Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- Usefulness and Limits of DOAC Removal Agents Based on Activated Charcoal in Thrombophilia Testing: Literature Review and Expert Proposals.Thrombosis and haemostasis · 2026Review
- Venous Thromboembolism Associated with Uterine Fibroids: A Review of Reported Cases.Journal of clinical medicine · 2026Review
- Case Report: Non-bacterial thrombotic endocarditis and multiple thrombi uncover a hidden prothrombotic mutation.Frontiers in cardiovascular medicine · 2026Article
- Rare inherited antithrombin deficiency presenting as spontaneous cerebral venous thrombosis with concomitant parenchymal hemorrhage: a case report.Frontiers in medicine · 2026Article
- The novel SERPINC1 missense mutation c.1148 T > A (p.L383H) causes hereditary antithrombin deficiency and thromboembolism in a Chinese family: a case report.Journal of medical case reports · 2025Article
- Influence of Factor V Leiden Mutation and Protein C and Protein S Deficiencies on Preeclampsia Among Sudanese Women.Cureus · 2025Article
- Review
- Admission deep venous thromboembolism of the lower extremity in patients of subtrochanteric fractures: a retrospective study.BMC musculoskeletal disorders · 2025Article
- Efficacy and safety of direct oral anticoagulants in patients with venous thrombosis and inherited thrombophilia.International journal of medical sciences · 2025Article
- Successful Conservative Treatment of Maternal Spontaneous Unilateral Adrenal Hemorrhage Causing Severe Anemia in the Third Trimester of Pregnancy-A Case Report.Medicina (Kaunas, Lithuania) · 2024Article
- Management of Patients Receiving Anticoagulation Therapy in Dental Practice: A Systematic Review.Healthcare (Basel, Switzerland) · 2024Review
- The Etiology of the Thrombotic Phenomena Involved in the Process of Coronary Artery Disease-What Is the Role of Thrombophilic Genes in the Development of This Pathology?International journal of molecular sciences · 2024Review
- Impact of Thrombophilic Polymorphisms in Antenatal Women on Perinatal Health: A Single-Center Prospective Study.Journal of personalized medicine · 2024Article
- Thrombophilia Testing: from Genetic Predisposition to Discrimination.TH open : companion journal to thrombosis and haemostasis · 2024Article
- Perioperative management of venous recanalization in a patient with inherited antithrombin deficiency: case report.Research and practice in thrombosis and haemostasis · 2024Article
- Simplified Method for Removing Direct Oral Anticoagulant Interference in Mechanical Coagulation Test Systems-A Proof of Concept.Journal of clinical medicine · 2024Article
- Management of Thrombosis in a Patient with Three Thrombophilic Disorders.Journal of blood medicine · 2024Article
- Article
- The methods for removal of direct oral anticoagulants and heparins to improve the monitoring of hemostasis: a narrative literature review.Thrombosis journal · 2023Review
- Dabigatran in Cerebral Sinus Vein Thrombosis and Thrombophilia.Life (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe inherited thrombophilia includes rare deficiencies of natural anticoagulants (antithrombin and proteins C and S) and homozygous or combined factor V Leiden and FII G20210A variants. They are associated with a high thrombosis risk and can impact the duration of anticoagulation therapy for patients with a venous thromboembolism (VTE) event. Therefore, it is important to diagnose thrombophilia and to use adapted anticoagulant therapy. The widespread use of direct anticoagulants (DOACs) for VTE has raised new issues concerning inherited thrombophilia. Concerning inherited thrombophilia diagnosis, DOACs are directed toward either FIIa or FXa and can therefore interfere with coagulation assays. This paper reports DOAC interference in several thrombophilia tests, including the assessment of antithrombin, protein S, and protein C activities. Antithrombin activity and clot-based assays used for proteins C and S can be overestimated, with a risk of missing a deficiency. The use of a device to remove DOACs should be considered to minimize the risk of false-negative results. The place of DOACs in the treatment of VTE in thrombophilia patients is also discussed. Available data are encouraging, but given the variability in thrombosis risk within natural anticoagulant deficiencies, evidence in patients with well-characterized thrombophilia would be useful.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.