Evidence map›Paper›PMID 35163726›Full record

ReviewInternational journal of molecular sciences2022

Optogenetics for Understanding and Treating Brain Injury: Advances in the Field and Future Prospects.

Yuwen Sun, Manrui Li, Shuqiang Cao, Yang Xu, Peiyan Wu, Shuting Xu, Qian Pan, Yadong Guo, Yi Ye, Zheng Wang and 4 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Biohybrid Photonic Platform for Subcellular Stimulation and Readout of In Vitro Neurons.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  3. Review
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuwen SunWest China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Manrui LiDepartment of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Shuqiang CaoDepartment of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Yang XuWest China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Peiyan WuWest China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Shuting XuWest China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Qian PanWest China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Yadong GuoDepartment of Forensic Science, School of Basic Medical Sciences, Central South University, Changsha 410013, China.
Yi YeDepartment of Forensic Toxicological Analysis, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China.
Zheng WangInstitute of Forensic Medicine, West China School of Basic Science and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Hao DaiDepartment of Forensic Pathology and Forensic Clinical Medicine, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Xiaoqi XieDepartment of West China Clinical Medicine, Sichuan University, Chengdu 610041, China.
Xiameng ChenDepartment of Forensic Pathology and Forensic Clinical Medicine, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.ORCID 0000-0003-4393-9053
Weibo LiangDepartment of Forensic Genetics, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-8487-3575

Funding

College Students' Innovative Entrepreneurial Training Plan Program 20220966Lthe Fundamental Research Funds for the Central Universities 20826041E4142
6 · The paper itself

Abstract

Optogenetics is emerging as an ideal method for controlling cellular activity. It overcomes some notable shortcomings of conventional methods in the elucidation of neural circuits, promotion of neuroregeneration, prevention of cell death and treatment of neurological disorders, although it is not without its own limitations. In this review, we narratively review the latest research on the improvement and existing challenges of optogenetics, with a particular focus on the field of brain injury, aiming at advancing optogenetics in the study of brain injury and collating the issues that remain. Finally, we review the most current examples of research, applying photostimulation in clinical treatment, and we explore the future prospects of these technologies.

Indexed as

Brain InjuriesNervous System DiseasesBrainHumansOptogeneticsneural circuitryneuronal apoptosisneuroregenerationopsinstraumatic brain injury

Identifiers

PMID35163726
PMCPMC8836693

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.