Evidence map›Paper›PMID 35163694›Full record

ArticleInternational journal of molecular sciences2022

Carboxamide Derivatives Are Potential Therapeutic AHR Ligands for Restoring IL-4 Mediated Repression of Epidermal Differentiation Proteins.

Gijs Rikken, Noa J M van den Brink, Ivonne M J J van Vlijmen-Willems, Piet E J van Erp, Lars Pettersson, Jos P H Smits, Ellen H van den Bogaard

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. CommensalFrontiers in immunology · 2025
    Article
  4. Comparative Efficacy ofMolecules (Basel, Switzerland) · 2024
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gijs RikkenDepartment of Dermatology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Nijmegen Medical Center (Radboudumc), 6525 GA Nijmegen, The Netherlands.ORCID 0000-0003-0535-5399
Noa J M van den BrinkDepartment of Dermatology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Nijmegen Medical Center (Radboudumc), 6525 GA Nijmegen, The Netherlands.
Ivonne M J J van Vlijmen-WillemsDepartment of Dermatology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Nijmegen Medical Center (Radboudumc), 6525 GA Nijmegen, The Netherlands.
Piet E J van ErpDepartment of Dermatology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Nijmegen Medical Center (Radboudumc), 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-6955-8817
Lars PetterssonImmunahr AB, Prästasvängen 21, 224 80 Lund, Sweden.
Jos P H SmitsDepartment of Dermatology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Nijmegen Medical Center (Radboudumc), 6525 GA Nijmegen, The Netherlands.ORCID 0000-0003-0915-8624
Ellen H van den BogaardDepartment of Dermatology, Radboud Institute for Molecular Life Sciences (RIMLS), Radboud University Nijmegen Medical Center (Radboudumc), 6525 GA Nijmegen, The Netherlands.
Radboud University Nijmegen · NL

Funding

National Institute of Health ES028244
6 · The paper itself

Abstract

Atopic dermatitis (AD) is a common T-helper 2 (Th2) lymphocyte-mediated chronic inflammatory skin disease characterized by disturbed epidermal differentiation (e.g.,

Indexed as

Cell DifferentiationBasic Helix-Loop-Helix ProteinsCells, CulturedFilaggrin ProteinsGene Expression RegulationHep G2 CellsHumansInterleukin-4KeratinocytesQuinolonesReceptors, Aryl HydrocarbonSignal TransductionAHR protein, humanBasic Helix-Loop-Helix ProteinsFilaggrin ProteinsIMA-07101Interleukin-4QuinolonesReceptors, Aryl Hydrocarbonaryl hydrocarbon receptoratopic dermatitiscarboxamide-3-quinolinedrug developmentfilaggrin

Identifiers

PMID35163694
PMCPMC8836151
OpenAlexW4210290557

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.