Evidence map›Paper›PMID 35163685›Full record

ArticleInternational journal of molecular sciences2022

Developing a Mathematical Model of Intracellular Calcium Dynamics for Evaluating Combined Anticancer Effects of Afatinib and RP4010 in Esophageal Cancer.

Yan Chang, Marah Funk, Souvik Roy, Elizabeth Stephenson, Sangyong Choi, Hristo V Kojouharov, Benito Chen, Zui Pan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yan ChangCollege of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX 76019, USA.
Marah FunkDepartment of Mathematics, The University of Texas at Arlington, Arlington, TX 76019, USA.
Souvik RoyDepartment of Mathematics, The University of Texas at Arlington, Arlington, TX 76019, USA.ORCID 0000-0002-6134-1381
Elizabeth StephensonDepartment of Mathematics, The University of Texas at Arlington, Arlington, TX 76019, USA.
Sangyong ChoiCollege of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX 76019, USA.
Hristo V KojouharovDepartment of Mathematics, The University of Texas at Arlington, Arlington, TX 76019, USA.
Benito ChenDepartment of Mathematics, The University of Texas at Arlington, Arlington, TX 76019, USA.ORCID 0000-0001-6377-4968
Zui PanCollege of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX 76019, USA.ORCID 0000-0003-4105-901X
The University of Texas at Arlington · USInstitute of Science and Technology Austria · ATUniversity of Connecticut · US

Funding

Oncogenic Function of Ca2+ Channel Orai1 in Esophageal CarcinogenesisR01CA185055 · NCI · OHIO STATE UNIVERSITY · PI CHEN, TONG, PAN, ZUI · 2015 to 2019
$1.6M
National Institute of Health R01 CA185055, S10OD0252300NCI NIH HHS R01 CA185055
6 · The paper itself

Abstract

Targeting dysregulated Ca

Indexed as

Models, BiologicalAfatinibAntineoplastic Combined Chemotherapy ProtocolsCalciumCell DeathCell Line, TumorCell SurvivalDrug SynergismErbB ReceptorsEsophageal NeoplasmsHumansOrganic ChemicalsAfatinibCalciumErbB ReceptorsOrganic ChemicalsRP4010esophageal cancerfluxes equationsOrai1store-operated Ca2+ entrytyrosine kinase inhibitor

Identifiers

PMID35163685
PMCPMC8836083
OpenAlexW4210357967

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.