Evidence map›Paper›PMID 35163660›Full record

ArticleInternational journal of molecular sciences2022

Conversion of Human Fibroblasts into Induced Neural Stem Cells by Small Molecules.

Donghui Liu, Grigori Rychkov, Plinio Hurtado, Hai-Yun Luo, Tao Zhang, Larisa Bobrovskaya, Xin-Fu Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Donghui LiuHealth and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.ORCID 0000-0002-6286-7385
Grigori RychkovHealth and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
Plinio HurtadoDepartment of Renal Medicine, The Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Hai-Yun LuoDepartment of Pharmacology, College of Basic Medicine, Kunming Medical University, Kunming 650500, China.
Tao ZhangDepartment of Pharmacology, College of Basic Medicine, Kunming Medical University, Kunming 650500, China.
Larisa BobrovskayaHealth and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
Xin-Fu ZhouHealth and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
University of South Australia · AUKunming Medical University · CNRoyal Adelaide Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Induced neural stem cells (iNSCs) reprogrammed from somatic cells hold great potentials for drug discovery, disease modelling and the treatment of neurological diseases. Although studies have shown that human somatic cells can be converted into iNSCs by introducing transcription factors, these iNSCs are unlikely to be used for clinical application due to the safety concern of using exogenous genes and viral transduction vectors. Here, we report the successful conversion of human fibroblasts into iNSCs using a cocktail of small molecules. Furthermore, our results demonstrate that these human iNSCs (hiNSCs) have similar gene expression profiles to bona fide NSCs, can proliferate, and are capable of differentiating into glial cells and functional neurons. This study collectively describes a novel approach based on small molecules to produce hiNSCs from human fibroblasts, which may be useful for both research and therapeutic purposes.

Indexed as

Cell DifferentiationAnimalsAstrocytesBiomarkersCell LineDown-RegulationElectrophysiological PhenomenaFibroblastsHumansMiceNeural Stem CellsNeuronsOligodendrogliaSmall Molecule LibrariesUp-RegulationBiomarkersSmall Molecule Librarieshuman fibroblastsinduced neuron stem cellssmall molecules

Identifiers

PMID35163660
PMCPMC8835839
OpenAlexW4210567085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.