Evidence map›Paper›PMID 35163639›Full record

ArticleInternational journal of molecular sciences2022

Magnesium Modified β-Tricalcium Phosphate Induces Cell Osteogenic Differentiation In Vitro and Bone Regeneration In Vivo.

Eisner Salamanca, Yu-Hwa Pan, Ying-Sui Sun, Hao-Wen Hsueh, Odontuya Dorj, Wan-Ling Yao, Jerry Chin-Yi Lin, Nai-Chia Teng, Ikki Watanabe, Shinichi Abe and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 4 countries.

Eisner SalamancaSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Yu-Hwa PanSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Ying-Sui SunSchool of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Hao-Wen HsuehSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0003-4217-7595
Odontuya DorjSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Wan-Ling YaoSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Jerry Chin-Yi LinSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Nai-Chia TengSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Ikki WatanabeDepartment of Gerontology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan.ORCID 0000-0002-2661-9608
Shinichi AbeDepartment of Anatomy, Tokyo Dental College, Tokyo 101-0061, Japan.ORCID 0000-0003-4632-9736
Yi-Fan WuSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0001-8872-6014
Wei-Jen ChangSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Taipei Medical University · TWChang Gung University · TWHarvard University · USMongolian National University of Medical Sciences · MNTaipei Medical University Hospital · TWTaipei Medical University-Shuang Ho Hospital · TWTokyo Dental College · JPTokyo Medical and Dental University · JP

Funding

Ministry of Science and Technology MOST 106-2314-B-038-017-MY2Southern Taiwan Science Park EX-04-15-19-110
6 · The paper itself

Abstract

In vitro, in vivo, and clinical studies have shown how the physicochemical and biological properties of β-tricalcium phosphate (β-TCP) work in bone regeneration. This study aimed to improve the properties of β-TCP by achieving optimum surface and bulk β-TCP chemical/physical properties through the hydrothermal addition of magnesium (Mg) and to later establish the biocompatibility of β-TCP/Mg for bone grafting and tissue engineering treatments. Multiple in vitro and in vivo analyses were used to complete β-TCP/Mg physicochemical and biological characterization. The addition of MgO brought about a modest rise in the number of β-TCP surface particles, indicating improvements in alkaline phosphatase (ALP) activity on day 21 (

Indexed as

Bone RegenerationCell DifferentiationOsteogenesisTissue ScaffoldsAnimalsCalcium PhosphatesCell LineHumansMagnesiumMaleRabbitsbeta-tricalcium phosphateCalcium PhosphatesMagnesiumbone regenerationdental researchhydrothermal synthesismagnesium ionsmaterial characterizationosteogenic differentiationβ-tricalcium phosphate

Identifiers

PMID35163639
PMCPMC8836187
OpenAlexW4210314757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.