Evidence map›Paper›PMID 35163623›Full record

ArticleInternational journal of molecular sciences2022

Inhibition of the Akt/PKB Kinase Increases Na

Mate Marosi, Miroslav N Nenov, Jessica Di Re, Nolan M Dvorak, Musaad Alshammari, Fernanda Laezza

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. mTORC2-NaChannels (Austin, Tex.) · 2026
    Article
  2. Identification of Bitter Peptides inFoods (Basel, Switzerland) · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Voltage-Gated NaLife (Basel, Switzerland) · 2023
    Review
  7. Article
  8. Glycogen Synthase Kinase 3: Ion Channels, Plasticity, and Diseases.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Mate MarosiDepartment of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Miroslav N NenovDepartment of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0001-6000-2372
Jessica Di ReDepartment of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-3819-1362
Nolan M DvorakDepartment of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0003-1280-9918
Musaad AlshammariDepartment of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-5165-1095
Fernanda LaezzaDepartment of Pharmacology & Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0003-1141-1852
The University of Texas Medical Branch at Galveston · USKing Saud University · SA

Funding

HOUSTON AREA MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008280 · NIGMS · RICE UNIVERSITY · PI WENSEL, THEODORE G · 1988 to 2023
$8.0M
Neurotrophin-dependent regulation of voltage-gated sodium channelsR01MH124351 · NIMH · UNIVERSITY OF TEXAS MED BR GALVESTON · PI LAEZZA, FERNANDA · 2020 to 2024
$3.0M
Neurotoxicology of deltamethrin in the developing brainR01ES031823 · NIEHS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GREEN, THOMAS ARTHUR, LAEZZA, FERNANDA · 2020 to 2024
$2.8M
King Saud University, Saudi Arabia, PhD scholarshipNIEHS NIH HHS R01 ES031823NIGMS NIH HHS T32 GM008280NIH HHS GM008280NIH HHS NIH/NIEHS-T32ES007254NIH HHS NIH/NIMH R01MH124351NIH HHS R01ES031823NIMH NIH HHS R01 MH124351
6 · The paper itself

Abstract

In neurons, changes in Akt activity have been detected in response to the stimulation of transmembrane receptors. However, the mechanisms that lead to changes in neuronal function upon Akt inhibition are still poorly understood. In the present study, we interrogate how Akt inhibition could affect the activity of the neuronal Na

Indexed as

Action PotentialsAnimalsHEK293 CellsHippocampusHumansMiceNAV1.6 Voltage-Gated Sodium ChannelProto-Oncogene Proteins c-aktPyramidal CellsNAV1.6 Voltage-Gated Sodium ChannelProto-Oncogene Proteins c-aktaxon initial segmentelectrophysiologyimmunohistochemistryneuronal excitabilityprotein kinase B (PKB)/Aktvoltage-gated sodium channels

Identifiers

PMID35163623
PMCPMC8836202
OpenAlexW4210456959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.