Evidence map›Paper›PMID 35163605›Full record

ArticleInternational journal of molecular sciences2022

Mesenchymal Stem Cells Delivery in Individuals with Different Pathologies: Multimodal Tracking, Safety and Future Applications.

Carolina Belmar-López, Georges Vassaux, Ana Medel-Martinez, Jerome Burnet, Miguel Quintanilla, Santiago Ramón Y Cajal, Javier Hernandez-Losa, Antonio De la Vieja, Pilar Martin-Duque

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carolina Belmar-LópezInstituto Aragonés de Ciencias de la Salud/IIS Aragón, 50009 Zaragoza, Spain.
Georges VassauxInstitut de Pharmacologie Moléculaire et Cellulaire, INSERM, CNRS, Université Côte d'Azur, 06560 Valbonne, France.ORCID 0000-0002-1149-7716
Ana Medel-MartinezInstituto Aragonés de Ciencias de la Salud/IIS Aragón, 50009 Zaragoza, Spain.ORCID 0000-0001-5783-4020
Jerome BurnetCancer Research UK, Queen Mary University of London, London E1 4NS, UK.
Miguel QuintanillaInstituto de Investigaciones Biomedicas Alberto Sols (CSIC-UAM), 28029 Madrid, Spain.ORCID 0000-0002-2124-7657
Santiago Ramón Y CajalPathology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.ORCID 0000-0002-3867-1390
Javier Hernandez-LosaPathology Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.ORCID 0000-0003-1526-3201
Antonio De la ViejaEndocrine Tumors Unit, Unidad Funcional de Investigación en Enfermedades Endocrinas (UFIEC), Instituto de Salud Carlos III (ISCIII), 28222 Majadahonda, Spain.ORCID 0000-0002-1187-1907
Pilar Martin-DuqueInstituto Aragonés de Ciencias de la Salud/IIS Aragón, 50009 Zaragoza, Spain.

Funding

Aragon Goverment Ph.D. Grant No.r B054/12Instituto de Salud Carlos lll CIBER-BBN and CIBERONCInstituto de Salud Carlos lll PI19/01007 and DTS21/00130Spanish Ministerio de Economía y Competitividad SAF2015-69964-R, RTI2018-099343-B-100
6 · The paper itself

Abstract

Due to their ease of isolation and their properties, mesenchymal stem cells (MSCs) have been widely investigated. MSCs have been proved capable of migration towards areas of inflammation, including tumors. Therefore, they have been suggested as vectors to carry therapies, specifically to neoplasias. As most of the individuals joining clinical trials that use MSCs for cancer and other pathologies are carefully recruited and do not suffer from other diseases, here we decided to study the safety and application of iv-injected MSCs in animals simultaneously induced with different inflammatory pathologies (diabetes, wound healing and tumors). We studied this by

Indexed as

Mesenchymal Stem Cell TransplantationNeoplasmsTumor MicroenvironmentAnimalsFemaleHeterograftsHumansMesenchymal Stem CellsMiceMice, Inbred BALB CMice, NudebioluminescencediabetesImaging PETinjuryluciferasemesenchymal stem cellsradioiodine therapysodium/iodide symporter (NIS)SPECTtherapytransdifferentiation

Identifiers

PMID35163605
PMCPMC8835939

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.