Evidence map›Paper›PMID 35163598›Full record

ArticleInternational journal of molecular sciences2022

PaOctβ2R: Identification and Functional Characterization of an Octopamine Receptor Activating Adenylyl Cyclase Activity in the American Cockroach

Wolfgang Blenau, Anna-Sophie Bremer, Yannik Schwietz, Daniel Friedrich, Lapo Ragionieri, Reinhard Predel, Sabine Balfanz, Arnd Baumann

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Wolfgang BlenauInstitute of Biochemistry, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0002-6874-4730
Anna-Sophie BremerInstitute of Biological Information Processing, IBI-1, Research Center Jülich, 52428 Jülich, Germany.
Yannik SchwietzDepartment of Biology, Philipps University of Marburg, 35037 Marburg, Germany.
Daniel FriedrichDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0003-2540-1663
Lapo RagionieriInstitute of Zoology, University of Cologne, 50923 Cologne, Germany.
Reinhard PredelInstitute of Zoology, University of Cologne, 50923 Cologne, Germany.
Sabine BalfanzInstitute of Biological Information Processing, IBI-1, Research Center Jülich, 52428 Jülich, Germany.
Arnd BaumannInstitute of Biological Information Processing, IBI-1, Research Center Jülich, 52428 Jülich, Germany.ORCID 0000-0001-9456-7275
Forschungszentrum Jülich · DEUniversity of Cologne · DEHarvard University · USLeipzig University · DEPhilipps University of Marburg · DE

Funding

Deutsche Forschungsgemeinschaft BL 469/4-4Deutsche Forschungsgemeinschaft PR766/11-1
6 · The paper itself

Abstract

Biogenic amines constitute an important group of neuroactive substances that control and modulate various neural circuits. These small organic compounds engage members of the guanine nucleotide-binding protein coupled receptor (GPCR) superfamily to evoke specific cellular responses. In addition to dopamine- and 5-hydroxytryptamine (serotonin) receptors, arthropods express receptors that are activated exclusively by tyramine and octopamine. These phenolamines functionally substitute the noradrenergic system of vertebrates Octopamine receptors that are the focus of this study are classified as either α- or β-adrenergic-like. Knowledge on these receptors is scarce for the American cockroach (

Indexed as

Adenylyl CyclasesCalcium SignalingInsect ProteinsPeriplanetaReceptors, Biogenic AmineAnimalsCyclic AMPOctopamineAdenylyl CyclasesCyclic AMPInsect Proteinsnorsynephrine receptorOctopamineReceptors, Biogenic Aminebiogenic aminescellular signalingcockroachgene annotationgene familyGPCRsecond messenger

Identifiers

PMID35163598
PMCPMC8835733
OpenAlexW4210550981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.