Evidence map›Paper›PMID 35163556›Full record

ArticleInternational journal of molecular sciences2022

MiR-29a Curbs Hepatocellular Carcinoma Incidence via Targeting of

Ying-Hsien Huang, Wei-Shiung Lian, Feng-Sheng Wang, Pei-Wen Wang, Hung-Yu Lin, Ming-Chao Tsai, Ya-Ling Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. LncRNATranslational cancer research · 2024
    Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. MiR-29a-3p: a potential biomarker and therapeutic target in colorectal cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ying-Hsien HuangDepartment of Pediatrics, Kaohsiung Chang Gung Memorial Hospital Chang, Kaohsiung 833, Taiwan.ORCID 0000-0002-7127-0046
Wei-Shiung LianCenter for Mitochondrial Research and Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Feng-Sheng WangCenter for Mitochondrial Research and Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Pei-Wen WangCenter for Mitochondrial Research and Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Hung-Yu LinResearch Assistant Center, Show Chwan Memorial Hospital, Changhua 500, Taiwan.ORCID 0000-0002-9035-5408
Ming-Chao TsaiDivision of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.ORCID 0000-0002-3613-2051
Ya-Ling YangCollege of Medicine, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0001-6914-3227
Chang Gung University · TWChang Bing Show Chwan Memorial Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A high-fat diet is responsible for hepatic fat accumulation that sustains chronic liver damage and increases the risks of steatosis and hepatocellular carcinoma (HCC). MicroRNA-29a (miR-29a), a key regulator of cellular behaviors, is present in anti-fibrosis and modulator tumorigenesis. However, the increased transparency of the correlation between miR-29a and the progression of human HCC is still further investigated. In this study, we predicted HIF-1α and ANGPT2 as regulators of HCC by the OncoMir cancer database and showed a strong positive correlation with HIF-1α and ANGPT2 gene expression in HCC patients. Mice fed the western diet (WD) while administered CCl4 for 25 weeks induced chronic liver damage and higher HCC incidence than without fed WD mice. HCC section staining revealed signaling upregulation in ki67, severe fibrosis, and steatosis in WD and CCl4 mice and detected Col3a1 gene expressions. HCC tissues significantly attenuated miR-29a but increased in HIF-1α, ANGPT2, Lox, Loxl2, and VEGFA expression. Luciferase activity analysis confirms that miR-29a specific binding 3'UTR of HIF-1α and ANGPT2 to repress expression. In summary, miR-29a control HIF-1α and ANGPT2 signaling in HCC formation. This study insight into a novel molecular pathway by which miR-29a targeting HIF-1α and ANGPT2 counteracts the incidence of HCC development.

Indexed as

3' Untranslated RegionsAngiopoietin-2AnimalsCarbon TetrachlorideCarcinoma, HepatocellularCell ProliferationGene Expression Regulation, NeoplasticHep G2 CellsHumansHypoxia-Inducible Factor 1, alpha SubunitIncidenceLiver NeoplasmsMaleMiceMicroRNAsSignal Transduction3' Untranslated RegionsAngiopoietin-2ANGPT2 protein, humanCarbon TetrachlorideHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitMicroRNAsMIRN29a microRNA, humanANGPT2hepatocellular carcinomaHIF-1αmiR-29a

Identifiers

PMID35163556
PMCPMC8835722
OpenAlexW4210602467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.