Evidence map›Paper›PMID 35163460›Full record

ArticleInternational journal of molecular sciences2022

Analysis of mRNA and Protein Levels of

Anna Di Maio, Arianna De Rosa, Silvia Pelucchi, Martina Garofalo, Benedetta Marciano, Tommaso Nuzzo, Fabrizio Gardoni, Andrea M Isidori, Monica Di Luca, Francesco Errico and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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  8. Pleiotropic Potential ofMolecules (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Anna Di MaioLaboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.
Arianna De RosaLaboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.ORCID 0000-0003-4985-1677
Silvia PelucchiDepartment of Pharmacological and Biomolecular Sciences (DiSFeB), University of Milan, 20133 Milan, Italy.
Martina GarofaloLaboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.
Benedetta MarcianoLaboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.
Tommaso NuzzoLaboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.
Fabrizio GardoniDepartment of Pharmacological and Biomolecular Sciences (DiSFeB), University of Milan, 20133 Milan, Italy.ORCID 0000-0003-4598-5563
Andrea M IsidoriDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Monica Di LucaDepartment of Pharmacological and Biomolecular Sciences (DiSFeB), University of Milan, 20133 Milan, Italy.
Francesco ErricoLaboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.
Andrea De BartolomeisSection of Psychiatry Laboratory of Molecular and Translational Psychiatry, Department of Neuroscience, Reproductive Science and Odontostomatology, School of Medicine, University "Federico II", 80131 Naples, Italy.
Elena MarcelloDepartment of Pharmacological and Biomolecular Sciences (DiSFeB), University of Milan, 20133 Milan, Italy.
Alessandro UsielloLaboratory of Translational Neuroscience, CEINGE Biotecnologie Avanzate, 80145 Naples, Italy.
Ceinge Biotecnologie Avanzate (Italy) · ITUniversity of Milan · ITUniversity of Campania "Luigi Vanvitelli" · ITFederico II University Hospital · ITSapienza University of Rome · IT

Funding

Brain and Behavior Research Foundation 20353Fondazione Cariplo 2018-0511Italian Ministry of University and Research 2017MYJ5THItalian Ministry of University and Research PRIN 2017B9NCSXMinistry of Education, Universities and Research 2017M42834NARSAD Young Investigator Grant 23968
6 · The paper itself

Abstract

Schizophrenia (SCZ) is a mental illness characterized by aberrant synaptic plasticity and connectivity. A large bulk of evidence suggests genetic and functional links between postsynaptic abnormalities and SCZ. Here, we performed quantitative PCR and Western blotting analysis in the dorsolateral prefrontal cortex (DLPFC) and hippocampus of SCZ patients to investigate the mRNA and protein expression of three key spine shapers: the actin-binding protein cyclase-associated protein 2 (

Indexed as

ADAM10 ProteinAdaptor Proteins, Signal TransducingAdultAgedAged, 80 and overAlzheimer DiseaseAmyloid Precursor Protein SecretasesAutopsyCase-Control StudiesDiscs Large Homolog 1 ProteinDorsolateral Prefrontal CortexFemaleGene Expression RegulationHippocampusHumansMaleADAM10 ProteinADAM10 protein, humanAdaptor Proteins, Signal TransducingAmyloid Precursor Protein SecretasesCAP2 protein, humanDiscs Large Homolog 1 ProteinDLG1 protein, humanMembrane ProteinsAlzheimer’s diseasedendritic spineParkinson’s diseasepostsynaptic densityschizophrenia

Identifiers

PMID35163460
PMCPMC8835961
OpenAlexW4210374253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.