Evidence map›Paper›PMID 35163444›Full record

ReviewInternational journal of molecular sciences2022

Role of the Transcription Factor FOSL1 in Organ Development and Tumorigenesis.

Vladimir V Sobolev, Asiat Z Khashukoeva, Olga E Evina, Natalia A Geppe, Svetlana N Chebysheva, Irina M Korsunskaya, Ekaterina Tchepourina, Alexandre Mezentsev

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 103 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Systematic and precise interventions for KRAS-mutant cancers.Experimental hematology & oncology · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Vladimir V SobolevCenter for Theoretical Problems in Physico-Chemical Pharmacology, Russian Academy of Sciences, 109029 Moscow, Russia.ORCID 0000-0003-4779-156X
Asiat Z KhashukoevaFederal State Autonomous Educational Institution of Higher Education, N.I. Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, 117997 Moscow, Russia.
Olga E Evina"JSC DK Medsi", Medical and Diagnostics Center, 125284 Moscow, Russia.
Natalia A GeppeNF Filatov Clinical Institute of Children's Health, I.M. Sechenov First MSMU, 119435 Moscow, Russia.
Svetlana N ChebyshevaNF Filatov Clinical Institute of Children's Health, I.M. Sechenov First MSMU, 119435 Moscow, Russia.
Irina M KorsunskayaCenter for Theoretical Problems in Physico-Chemical Pharmacology, Russian Academy of Sciences, 109029 Moscow, Russia.
Ekaterina TchepourinaCenter for Theoretical Problems in Physico-Chemical Pharmacology, Russian Academy of Sciences, 109029 Moscow, Russia.
Alexandre MezentsevCenter for Theoretical Problems in Physico-Chemical Pharmacology, Russian Academy of Sciences, 109029 Moscow, Russia.
Center for Theoretical Problems of Physicochemical Pharmacology · RUPirogov Russian National Research Medical University · RURussian Research Center for Molecular Diagnostics and Therapy · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transcription factor FOSL1 plays an important role in cell differentiation and tumorigenesis. Primarily, FOSL1 is crucial for the differentiation of several cell lineages, namely adipocytes, chondrocytes, and osteoblasts. In solid tumors, FOSL1 controls the progression of tumor cells through the epithelial-mesenchymal transformation. In this review, we summarize the available data on FOSL1 expression, stabilization, and degradation in the cell. We discuss how FOSL1 is integrated into the intracellular signaling mechanisms and provide a comprehensive analysis of FOSL1 influence on gene expression. We also analyze the pathological changes caused by altered

Indexed as

MutationAnimalsCarcinogenesisCell DifferentiationCell ProliferationEpithelial-Mesenchymal TransitionFos-Related Antigen 1Gene Expression Regulation, NeoplasticHumansMiceProtein StabilityProteolysisProto-Oncogene Proteins c-fosFos-Related Antigen 1Proto-Oncogene Proteins c-foscell differentiationFOSL1/FRA1gene expression promoterorgan developmenttranscription factortumorigenesis

Identifiers

PMID35163444
PMCPMC8835756
OpenAlexW4213158104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.