Evidence map›Paper›PMID 35163369›Full record

ArticleInternational journal of molecular sciences2022

4-Acetylantroquinonol B Suppresses Prostate Cancer Growth and Angiogenesis via a VEGF/PI3K/ERK/mTOR-Dependent Signaling Pathway in Subcutaneous Xenograft and In Vivo Angiogenesis Models.

Tur-Fu Huang, Shih-Wei Wang, Yu-Wei Lai, Shih-Chia Liu, Yu-Jen Chen, Thomas Y Hsueh, Chih-Chung Lin, Chun-Hsuan Lin, Ching-Hu Chung

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. International journal of molecular sciences · 2025
    Article
  5. Review
  6. Article
  7. Targeting PI3K/Akt signaling in prostate cancer therapy.Journal of cell communication and signaling · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Anti-Inflammatory Constituents ofMolecules (Basel, Switzerland) · 2022
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Tur-Fu HuangInstitute of Pharmacology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.
Shih-Wei WangDepartment of Medicine, Mackay Medical College, New Taipei City 252, Taiwan.ORCID 0000-0001-7522-6352
Yu-Wei LaiDivision of Urology, Taipei City Hospital Renai Branch, Taipei 103, Taiwan.
Shih-Chia LiuDepartment of Orthopaedics, MacKay Memorial Hospital, Taipei 104, Taiwan.
Yu-Jen ChenDepartment of Radiation Oncology, MacKay Memorial Hospital, Taipei 104, Taiwan.ORCID 0000-0001-9794-8938
Thomas Y HsuehDivision of Urology, Taipei City Hospital Renai Branch, Taipei 103, Taiwan.
Chih-Chung LinDepartment of Pharmacy, Taichung Veterans General Hospital Puli Branch, Nantou 545, Taiwan.
Chun-Hsuan LinDepartment of Medicine, Mackay Medical College, New Taipei City 252, Taiwan.
Ching-Hu ChungDepartment of Medicine, Mackay Medical College, New Taipei City 252, Taiwan.ORCID 0000-0002-3096-8974
Mackay Medical University · TWMackay Memorial Hospital · TWNational Taiwan University · TWNational Yang Ming Chiao Tung University · TWTaipei City Hospital · TW

Funding

Mackay Medical College MMC-RD-110-1B-P01Mackay Medical College MMC-RD-110-CF-G001-0MacKay Memorial Hospital MMH-104-92Ministry of Science and Technology of Taiwan 104-2320-B-715-003Ministry of Science and Technology of Taiwan 107-2320-B-715-003-MY3Ministry of Science and Technology of Taiwan MOST 102-2320-B-715-002-MY2Taipei City Hospital TCH-10501-62-043
6 · The paper itself

Abstract

Prostate cancer is a major cause of cancer-related mortality in men in developed countries. The compound, 4-acetylantroquinonol B (4AAQB), is isolated from

Indexed as

4-ButyrolactoneAngiogenesis InhibitorsCell MovementCell ProliferationCell SurvivalCyclohexanonesGene Expression Regulation, NeoplasticHumansHuman Umbilical Vein Endothelial CellsMalePC-3 CellsPhosphatidylinositol 3-KinaseProstatic NeoplasmsProto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine Kinases4-acetylantroquinonol B4-ButyrolactoneAngiogenesis InhibitorsCyclohexanonesMTOR protein, humanPhosphatidylinositol 3-KinaseProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesVascular Endothelial Growth Factor AVEGFA protein, human4AAQBangiogenesisAntrodia cinnamomeametastasisprostate cancerVEGF

Identifiers

PMID35163369
PMCPMC8836157
OpenAlexW4210534954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.