Evidence map›Paper›PMID 35163281›Full record

ArticleInternational journal of molecular sciences2022

Calycosin, a Common Dietary Isoflavonoid, Suppresses Melanogenesis through the Downregulation of PKA/CREB and p38 MAPK Signaling Pathways.

Kun-Chang Wu, You-Cheng Hseu, Yu-Ching Shih, Govindan Sivakumar, Jyun-Ting Syu, Guan-Lin Chen, Meng-Tien Lu, Po-Chen Chu

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
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  12. Phenolic acids inJournal of ginseng research · 2023
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  15. The Effects of 2International journal of molecular sciences · 2023
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  16. Article
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  18. Extraction and Concentration of WasteInternational journal of molecular sciences · 2022
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Kun-Chang WuSchool of Pharmacy, College of Pharmacy, China Medical University, Taichung 406040, Taiwan.
You-Cheng HseuDepartment of Cosmeceutics and Graduate Institute of Cosmeceutics, China Medical University, Taichung 406040, Taiwan.ORCID 0000-0001-5307-6162
Yu-Ching ShihDepartment of Cosmeceutics and Graduate Institute of Cosmeceutics, China Medical University, Taichung 406040, Taiwan.
Govindan SivakumarDrug Development Center, China Medical University, Taichung 406040, Taiwan.ORCID 0000-0002-1004-0060
Jyun-Ting SyuDepartment of Cosmeceutics and Graduate Institute of Cosmeceutics, China Medical University, Taichung 406040, Taiwan.
Guan-Lin ChenDepartment of Cosmeceutics and Graduate Institute of Cosmeceutics, China Medical University, Taichung 406040, Taiwan.
Meng-Tien LuDepartment of Cosmeceutics and Graduate Institute of Cosmeceutics, China Medical University, Taichung 406040, Taiwan.ORCID 0000-0002-8132-4802
Po-Chen ChuDepartment of Cosmeceutics and Graduate Institute of Cosmeceutics, China Medical University, Taichung 406040, Taiwan.ORCID 0000-0001-9510-2269
China Medical University · TW

Funding

China Medical University CMU109-Z-07China Medical University CMU110-Z-07
6 · The paper itself

Abstract

Calycosin, a bioactive isoflavonoid isolated from root extracts of

Indexed as

alpha-MSHAnimalsAstragalus propinquusCell Line, TumorCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element-Binding ProteinDown-RegulationGene ExpressionGene Expression Regulation, NeoplasticIsoflavonesMAP Kinase Signaling SystemMelaninsMelanomaMicrophthalmia-Associated Transcription Factorp38 Mitogen-Activated Protein KinasesPhosphorylation7,3'-dihydroxy-4'-methoxyisoflavonealpha-MSHCyclic AMP-Dependent Protein KinasesCyclic AMP Response Element-Binding ProteinIsoflavonesMelaninsMicrophthalmia-Associated Transcription Factorp38 Mitogen-Activated Protein KinasesPlant ExtractscalycosinmelaninMITFp38 MAPKPKA/CREBTRP-2tyrosinase

Identifiers

PMID35163281
PMCPMC8836186
OpenAlexW4210548674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.