Evidence map›Paper›PMID 35163276›Full record

ArticleInternational journal of molecular sciences2022

Investigating the Molecular Mechanisms of Renal Hepcidin Induction and Protection upon Hemoglobin-Induced Acute Kidney Injury.

Laura E Diepeveen, Gaby Stegemann, Erwin T Wiegerinck, Rian Roelofs, Myrthe Naber, Olivier Lóreal, Bart Smeets, Frank Thévenod, Dorine W Swinkels, Rachel P L van Swelm

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. The role and mechanism of heme oxygenase-1 in arrhythmias.Journal of molecular medicine (Berlin, Germany) · 2024
    Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 4 countries.

Laura E DiepeveenTranslational Metabolic Laboratory (TML-830), Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Gaby StegemannTranslational Metabolic Laboratory (TML-830), Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Erwin T WiegerinckTranslational Metabolic Laboratory (TML-830), Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Rian RoelofsTranslational Metabolic Laboratory (TML-830), Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Myrthe NaberTranslational Metabolic Laboratory (TML-830), Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Olivier LórealINSERM 1241, Nutrition, Metabolisms and Cancer (NuMeCan) Institute, University of Rennes, 35033 Rennes, France.
Bart SmeetsDepartment of Pathology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Frank ThévenodInstitute of Physiology, Pathophysiology and Toxicology, Center for Biomedical Training and Research (ZBAF), University of Witten/Herdecke, 58455 Witten, Germany.ORCID 0000-0001-8663-3498
Dorine W SwinkelsTranslational Metabolic Laboratory (TML-830), Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.ORCID 0000-0002-1040-9446
Rachel P L van SwelmTranslational Metabolic Laboratory (TML-830), Department of Laboratory Medicine, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Radboud University Nijmegen · NLInserm · FRWitten/Herdecke University · DE

Funding

Nierstichting 16OKG04
6 · The paper itself

Abstract

Hemolysis is known to cause acute kidney injury (AKI). The iron regulatory hormone hepcidin, produced by renal distal tubules, is suggested to exert a renoprotective role during this pathology. We aimed to elucidate the molecular mechanisms of renal hepcidin synthesis and its protection against hemoglobin-induced AKI. In contrast to known hepatic hepcidin induction, incubation of mouse cortical collecting duct (mCCD

Indexed as

Acute Kidney InjuryAnimalsHeminHemoglobinsHemolysisHepcidinsIronKidneyKidney Tubules, DistalMiceMice, KnockoutOxidative StressHamp protein, mouseHeminHemoglobinsHepcidinsIronacute kidney injuryhemoglobinhepcidinironkidney

Identifiers

PMID35163276
PMCPMC8835743
OpenAlexW4210392739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.