Evidence map›Paper›PMID 35163252›Full record

ReviewInternational journal of molecular sciences2022

Emerging Connections between Nuclear Pore Complex Homeostasis and ALS.

Sunandini Chandra, C Patrick Lusk

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Molecular hallmarks of ageing in amyotrophic lateral sclerosis.Cellular and molecular life sciences : CMLS · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sunandini ChandraDepartment of Cell Biology, Yale School of Medicine, 295 Congress Ave, New Haven, CT 06520, USA.ORCID 0000-0001-5386-0934
C Patrick LuskDepartment of Cell Biology, Yale School of Medicine, 295 Congress Ave, New Haven, CT 06520, USA.ORCID 0000-0003-4703-0533
Yale University · US

Funding

Nuclear pore complex quality control in ALS/FTDR01NS122236 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LUSK, CHARLES PATRICK, ROTHSTEIN, JEFFREY D · 2021 to 2025
$4.0M
NIH HHS R01 NS122236NINDS NIH HHS R01 NS122236
6 · The paper itself

Abstract

Developing effective treatments for neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) requires understanding of the underlying pathomechanisms that contribute to the motor neuron loss that defines the disease. As it causes the largest fraction of familial ALS cases, considerable effort has focused on hexanucleotide repeat expansions in the

Indexed as

Active Transport, Cell NucleusAmyotrophic Lateral SclerosisHomeostasisHumansMotor NeuronsNuclear PoreC9ORF72 ALSCHMP7ESCRTNPC injurynuclear quality controlnuclear transportPOM121

Identifiers

PMID35163252
PMCPMC8835831
OpenAlexW4210493568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.