Evidence map›Paper›PMID 35163243›Full record

ArticleInternational journal of molecular sciences2022

Impaired Intracellular Ca

Enrico Pierantozzi, Péter Szentesi, Cecilia Paolini, Beatrix Dienes, János Fodor, Tamás Oláh, Barbara Colombini, Dilson E Rassier, Egidio Maria Rubino, Stephan Lange and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. The varied functions of the giant muscle scaffold protein obscurin.Frontiers in cell and developmental biology · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 5 countries.

Enrico PierantozziDepartment of Molecular and Developmental Medicine, Molecular Medicine Section, University of Siena, 53100 Siena, Italy.
Péter SzentesiDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4002 Debrecen, Hungary.ORCID 0000-0003-2621-2282
Cecilia PaoliniDepartment of Neuroscience, Imaging and Clinical Sciences, University Gabriele d' Annunzio of Chieti, 66100 Chieti, Italy.
Beatrix DienesDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4002 Debrecen, Hungary.ORCID 0000-0002-3110-0296
János FodorDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4002 Debrecen, Hungary.
Tamás OláhDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4002 Debrecen, Hungary.
Barbara ColombiniDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0003-1397-9791
Dilson E RassierDepartment of Kinesiology and Physical Education, McGill University, Montreal, QC H2W 1S4, Canada.ORCID 0000-0001-7080-9364
Egidio Maria RubinoDepartment of Molecular and Developmental Medicine, Molecular Medicine Section, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-6710-7318
Stephan LangeBiomedical Research Facility 2, School of Medicine, University of California, La Jolla, CA 92093, USA.ORCID 0000-0001-9361-6602
Daniela RossiDepartment of Molecular and Developmental Medicine, Molecular Medicine Section, University of Siena, 53100 Siena, Italy.
László CsernochDepartment of Physiology, Faculty of Medicine, University of Debrecen, H-4002 Debrecen, Hungary.ORCID 0000-0002-2446-1456
Maria Angela BagniDepartment of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.ORCID 0000-0001-9692-3034
Carlo ReggianiDepartment of Biomedical Science, University of Padova, 35121 Padova, Italy.ORCID 0000-0001-8080-361X
Vincenzo SorrentinoDepartment of Molecular and Developmental Medicine, Molecular Medicine Section, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-8573-8631
University of Debrecen · HUUniversity of Siena · ITUniversity of Florence · ITMcGill University · CAUniversity of California San Diego · USUniversity of Chieti-Pescara · ITUniversity of Padua · IT

Funding

The role of obscurin and Obsl1 as key determinants for diastolic functionR01HL152251 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHO, YOSHITAKE, LANGE, STEPHAN · 2021 to 2024
$2.3M
NHLBI NIH HHS R01 HL152251
6 · The paper itself

Abstract

Obscurin is a giant sarcomeric protein expressed in striated muscles known to establish several interactions with other proteins of the sarcomere, but also with proteins of the sarcoplasmic reticulum and costameres. Here, we report experiments aiming to better understand the contribution of obscurin to skeletal muscle fibers, starting with a detailed characterization of the diaphragm muscle function, which we previously reported to be the most affected muscle in obscurin (

Indexed as

AnimalsAnkyrinsCalciumConnectinMaleMiceMice, KnockoutMuscle ContractionMuscle Fibers, SkeletalMuscle ProteinsMuscle, SkeletalPhysical Conditioning, AnimalProtein Serine-Threonine KinasesRho Guanine Nucleotide Exchange FactorsSarcomeresSarcoplasmic ReticulumAnkyrinsCalciumConnectinMuscle Proteinsobscn protein, mouseProtein Serine-Threonine KinasesRho Guanine Nucleotide Exchange FactorsSarcoplasmic Reticulum Calcium-Transporting ATPasescalcium dynamicsexercisekinetics of contractionmuscle fiber damageobscurinsarcoplasmic reticulumskeletal muscle

Identifiers

PMID35163243
PMCPMC8835721
OpenAlexW4210328833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.