Evidence map›Paper›PMID 35163231›Full record

ArticleInternational journal of molecular sciences2022

Protein Biochemistry and Molecular Modeling of the Intra-Melanosomal Domain of Human Recombinant Tyrp2 Protein and OCA8-Related Mutant Variants.

Monika B Dolinska, Taariq Woods, Isabella Osuna, Yuri V Sergeev

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Valorization of Hom Thong Banana Peel (International journal of molecular sciences · 2024
    Article
  3. Article
  4. Article
  5. TheGenes · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Monika B DolinskaNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Taariq WoodsNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Isabella OsunaNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Yuri V SergeevNational Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-7204-6572
National Institutes of Health · US

Funding

Proteins From Hereditary Eye Diseases: In-silico and Experimental StudiesZIAEY000476 · NEI · NATIONAL EYE INSTITUTE · PI SERGEEV, YURI · 2009 to 2025
$16.8M
NEI NIH HHS ZIA EY000476-10
6 · The paper itself

Abstract

Tyrosinase-related protein 2 (Tyrp2) is involved in the melanogenesis pathway, catalyzing the tautomerization of dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA). Recently, a new type of albinism was discovered with disease-causing mutations in the

Indexed as

AlbinismAlbinism, OculocutaneousCatalysisHumansIntramolecular OxidoreductasesKineticsMelaninsMelanosomesModels, MolecularMolecular Docking SimulationOxidoreductasesProtein DomainsProtein StabilityRecombinant Proteinsdopachrome isomeraseIntramolecular OxidoreductasesMelaninsOxidoreductasesRecombinant ProteinsCys-rich domaineffect of reducerintra-melanosomal domainOCA8-related mutant variantsprotein expression/purificationprotein stabilitytyrosinase-related protein 2

Identifiers

PMID35163231
PMCPMC8836267
OpenAlexW4210497186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.