Evidence map›Paper›PMID 35163224›Full record

ArticleInternational journal of molecular sciences2022

Aberrant Methylation of 20 miRNA Genes Specifically Involved in Various Steps of Ovarian Carcinoma Spread: From Primary Tumors to Peritoneal Macroscopic Metastases.

Vitaly I Loginov, Irina V Pronina, Elena A Filippova, Alexey M Burdennyy, Svetlana S Lukina, Tatiana P Kazubskaya, Leonid A Uroshlev, Marina V Fridman, Olga I Brovkina, Natalya V Apanovich and 5 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Role of MicroRNAs in Cancer Development and Treatment.International journal of molecular sciences · 2023
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. An interactive analysis of the mouse oviductal miRNA profiles.Frontiers in cell and developmental biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Vitaly I LoginovInstitute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
Irina V ProninaInstitute of General Pathology and Pathophysiology, 125315 Moscow, Russia.ORCID 0000-0002-0423-7801
Elena A FilippovaInstitute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
Alexey M BurdennyyInstitute of General Pathology and Pathophysiology, 125315 Moscow, Russia.ORCID 0000-0002-9398-8075
Svetlana S LukinaInstitute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
Tatiana P KazubskayaN.N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russia.
Leonid A UroshlevInstitute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
Marina V FridmanVavilov Institute of General Genetics, Russian Academy of Sciences, 119991 Moscow, Russia.
Olga I BrovkinaInstitute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
Natalya V ApanovichResearch Center for Medical Genetics, 115478 Moscow, Russia.ORCID 0000-0002-9221-115X
Alexander V KarpukhinResearch Center for Medical Genetics, 115478 Moscow, Russia.
Ivan S StilidiN.N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russia.
Nikolay E KushlinskiiN.N. Blokhin National Medical Research Center of Oncology, 115478 Moscow, Russia.
Alexey A DmitrievEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.ORCID 0000-0002-6827-9584
Eleonora A BragaInstitute of General Pathology and Pathophysiology, 125315 Moscow, Russia.ORCID 0000-0001-5188-4094
Research Institute of General Pathology and Pathophysiology, the Russian Academy of Medical Sciences · RUResearch Centre for Medical Genetics · RUEngelhardt Institute of Molecular Biology · RUVavilov Institute of General Genetics · RU

Funding

Russian Science Foundation 20-15-00368
6 · The paper itself

Abstract

Our work aimed to differentiate 20 aberrantly methylated miRNA genes that participate at different stages of development and metastasis of ovarian carcinoma (OvCa) using methylation-specific qPCR in a representative set of clinical samples: 102 primary tumors without and with metastases (to lymph nodes, peritoneum, or distant organs) and 30 peritoneal macroscopic metastases (PMM). Thirteen miRNA genes (

Indexed as

CarcinomaCarcinoma, Ovarian EpithelialFemaleGene ExpressionGene Expression Regulation, NeoplasticHumansMachine LearningMethylationMicroRNAsNeoplasm MetastasisNeoplasm Recurrence, LocalNeoplasm StagingOvarian NeoplasmsPeritoneumPrognosisRecurrenceMicroRNAsDNA methylationgene expressionmetastatic primary tumorsmiRNA genesovarian carcinomaoverall survivalperitoneal metastases

Identifiers

PMID35163224
PMCPMC8835734
OpenAlexW4210538815

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.