ArticleInternational journal of molecular sciences2022
Role of Dorsomedial Hypothalamus GABAergic Neurons in Sleep-Wake States in Response to Changes in Ambient Temperature in Mice.
Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 19 citations in OpenAlex.
- Hypothalamic thermoregulatory neurons divergently modulate isoflurane anesthesia via temperature dependent and independent mechanisms.iScience · 2026Article
- Nighttime temperature and sleep duration in the Chinese population.BMC public health · 2026Article
- Perspective for Modulation of Hypothalamic Neurogenesis: Integrating Anatomical Insights with Exercise and Dietary Interventions.International journal of molecular sciences · 2025Review
- Protective effects of jujube seed extract against oxidative stress in HT22 cells and its sleep-promoting action through GABAergic receptors.Journal of food and drug analysis · 2025Article
- Chronic Treatment of a Mouse Model of Cerebral Amyloid Angiopathy and Brain ATbioRxiv : the preprint server for biology · 2025Article
- [Activation of astrocytes in the dorsomedial hypothalamus accelerates sevoflurane anesthesia emergence in mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Hypothalamic Regulation of Cardiorespiratory Functions: Insights into the Dorsomedial and Perifornical Pathways.Biology · 2024Review
- Microglia mediate the increase in slow-wave sleep associated with high ambient temperature.The journal of physiological sciences : JPS · 2024Article
- Mapping of afferent and efferent connections of phenylethanolamine N-methyltransferase-expressing neurons in the nucleus tractus solitarii.CNS neuroscience & therapeutics · 2024Article
- A clock-dependent brake for rhythmic arousal in the dorsomedial hypothalamus.Nature communications · 2023Article
- Inputs and Outputs of the Mammalian Circadian Clock.Biology · 2023Review
- Neurotransmitters in Type 2 Diabetes and the Control of Systemic and Central Energy Balance.Metabolites · 2023Review
- GABAergic neurons in the dorsomedial hypothalamus regulate states of consciousness in sevoflurane anesthesia.iScience · 2023Article
- Neuroprotective effect of Ziziphi Spinosae Semen on rats with p-chlorophenylalanine-induced insomniaFrontiers in pharmacology · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
Good sleep quality is essential for maintaining the body's attention during wakefulness, which is easily affected by external factors such as an ambient temperature. However, the mechanism by which an ambient temperature influences sleep-wake behaviors remains unclear. The dorsomedial hypothalamus (DMH) has been reported to be involved in thermoregulation. It also receives projection from the preoptic area, which is an important region for sleep and energy homeostasis and the suprachiasmatic nucleus-a main control area of the clock rhythm. Therefore, we hypothesized that the DMH plays an important role in the regulation of sleep related to ambient temperatures. In this study, we found that cold exposure (24/20/16/12 °C) increased wakefulness and decreased non-rapid eye movement (NREM) sleep, while warm exposure (32/36/40/44 °C) increased NREM sleep and decreased wakefulness compared to 28 °C conditions in wild-type mice. Then, using non-specific and specific apoptosis, we found that lesions of whole DMH neurons and DMH γ-aminobutyric acid (GABA)-ergic neurons induced by caspase-3 virus aggravated the fluctuation of core body temperature after warm exposure and attenuated the change in sleep-wake behaviors during cold and warm exposure. However, chemogenetic activation or inhibition of DMH GABAergic neurons did not affect the sleep-wake cycle. Collectively, our findings reveal an essential role of DMH GABAergic neurons in the regulation of sleep-wake behaviors elicited by a change in ambient temperature.
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