Evidence map›Paper›PMID 35163144›Full record

ArticleInternational journal of molecular sciences2022

Deep Resequencing of 9 Candidate Genes Identifies a Role for ARAP1 and IGF2BP2 in Modulating Insulin Secretion Adjusted for Insulin Resistance in Obese Southern Europeans.

Diego Bailetti, Federica Sentinelli, Sabrina Prudente, Flavia Agata Cimini, Ilaria Barchetta, Maria Totaro, Alessia Di Costanzo, Arcangelo Barbonetti, Frida Leonetti, Maria Gisella Cavallo and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Molecular Effects of Physical Activity and Body Composition: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2025
    Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Diego BailettiDepartment of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, 67100 L'Aquila, Italy.
Federica SentinelliDepartment of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, 67100 L'Aquila, Italy.
Sabrina PrudenteResearch Unit of Metabolic and Cardiovascular Diseases, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.
Flavia Agata CiminiDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Ilaria BarchettaDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-0530-8568
Maria TotaroDepartment of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, 67100 L'Aquila, Italy.
Alessia Di CostanzoDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Arcangelo BarbonettiDepartment of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-6888-9585
Frida LeonettiDiabetes Unit, Department of Medical-Surgical Sciences and Biotechnologies, Santa Maria Goretti Hospital, Sapienza University of Rome, 04100 Latina, Italy.
Maria Gisella CavalloDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-6630-8049
Marco Giorgio BaroniDepartment of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, 67100 L'Aquila, Italy.ORCID 0000-0002-3224-6078
University of L'Aquila · ITSapienza University of Rome · ITCasa Sollievo della Sofferenza · ITOspedale Santa Maria Goretti · IT

Funding

Fondazione Diabete Ricerca (Fo.Di.Ri.) 2-years grantItalian Ministry of Health Ricerca Corrente 2018-2021Sapienza University of Rome AR116154E71B4EA5Sapienza University of Rome RM11715C3FCB9431
6 · The paper itself

Abstract

Type 2 diabetes is characterized by impairment in insulin secretion, with an established genetic contribution. We aimed to evaluate common and low-frequency (1-5%) variants in nine genes strongly associated with insulin secretion by targeted sequencing in subjects selected from the extremes of insulin release measured by the disposition index. Collapsing data by gene and/or function, the association between disposition index and nonsense variants were significant, also after adjustment for confounding factors (OR = 0.25, 95% CI = 0.11-0.59,

Indexed as

Insulin ResistanceInsulin SecretionPolymorphism, Single NucleotideAdultCarrier ProteinsCohort StudiesDiabetes Mellitus, Type 2FemaleGenetic Predisposition to DiseaseGTPase-Activating ProteinsHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedObesityRNA-Binding ProteinsARAP1 protein, humanCarrier ProteinsGTPase-Activating ProteinsIGF2BP2 protein, humanRNA-Binding Proteinsdiabetesdisposition indexextremesinsulin resistanceinsulin secretionnext-generation sequencingobesitytargeted resequencing

Identifiers

PMID35163144
PMCPMC8835579
OpenAlexW4207075987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.