Evidence map›Paper›PMID 35163120›Full record

ArticleInternational journal of molecular sciences2022

In Vivo Biocompatibility Investigation of an Injectable Calcium Carbonate (Vaterite) as a Bone Substitute including Compositional Analysis via SEM-EDX Technology.

Ronald E Unger, Sanja Stojanovic, Laura Besch, Said Alkildani, Romina Schröder, Ole Jung, Caroline Bogram, Oliver Görke, Stevo Najman, Wolfgang Tremel and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Biphasic bone substitutes coated with PLGA incorporating therapeutic ions SrFrontiers in bioengineering and biotechnology · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. In vivo (Athens, Greece)
    Article
  8. Low-temperatureIn vivo (Athens, Greece)
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Ronald E UngerRepair-Lab, Institute of Pathology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.ORCID 0000-0003-2482-9705
Sanja StojanovicDepartment of Biology and Human Genetics, Faculty of Medicine, University of Niš, 18108 Niš, Serbia.
Laura BeschInstitute of Inorganic Chemistry and Analytical Chemistry, Johannes Gutenberg-University of Mainz, 55128 Mainz, Germany.
Said AlkildaniBerlinAnalytix GmbH, Ullsteinstrasse 108, 12109 Berlin, Germany.
Romina SchröderInstitute of Inorganic Chemistry and Analytical Chemistry, Johannes Gutenberg-University of Mainz, 55128 Mainz, Germany.
Ole JungClinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, Germany.ORCID 0000-0001-8005-2916
Caroline BogramBerlinAnalytix GmbH, Ullsteinstrasse 108, 12109 Berlin, Germany.
Oliver GörkeInstitute of Materials Science and Technology, Chair of Advanced Ceramic Materials, Technical University Berlin, Hardenbergstr. 40, 10623 Berlin, Germany.ORCID 0000-0002-7978-2484
Stevo NajmanDepartment of Biology and Human Genetics, Faculty of Medicine, University of Niš, 18108 Niš, Serbia.ORCID 0000-0002-2411-9802
Wolfgang TremelInstitute of Inorganic Chemistry and Analytical Chemistry, Johannes Gutenberg-University of Mainz, 55128 Mainz, Germany.ORCID 0000-0002-4536-994X
Mike BarbeckInstitute of Materials Science and Technology, Chair of Advanced Ceramic Materials, Technical University Berlin, Hardenbergstr. 40, 10623 Berlin, Germany.ORCID 0000-0002-3001-1347
Johannes Gutenberg University Mainz · DETechnische Universität Berlin · DEUniversity of Nis · RSUniversity of Rostock · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Injectable bone substitutes (IBS) are increasingly being used in the fields of orthopedics and maxillofacial/oral surgery. The rheological properties of IBS allow for proper and less invasive filling of bony defects. Vaterite is the most unstable crystalline polymorph of calcium carbonate and is known to be able to transform into hydroxyapatite upon contact with an organic fluid (e.g., interstitial body fluid). Two different concentrations of hydrogels based on poly(ethylene glycol)-acetal-dimethacrylat (PEG-a-DMA), i.e., 8% (

Indexed as

Bone RegenerationWound HealingAnimalsBiocompatible MaterialsBone SubstitutesCalcium CarbonateElectron Probe MicroanalysisHydrogelsMacrophagesMaleMiceMice, Inbred BALB CMicroscopy, Electron, ScanningPolyethylene GlycolsSpectrometry, X-Ray EmissionBiocompatible MaterialsBone SubstitutesCalcium CarbonateHydrogelsPolyethylene Glycolsbiomaterial-induced multinucleated giant cellsbone tissue engineeringcalcium carbonateEDX mappingguided bone regenerationinjectable bone substitutesvaterite

Identifiers

PMID35163120
PMCPMC8835873
OpenAlexW4206910266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.