Evidence map›Paper›PMID 35163114›Full record

ArticleInternational journal of molecular sciences2022

The Signaling Pathway That cGAMP Riboswitches Found: Analysis and Application of Riboswitches to Study cGAMP Signaling in

Zhesen Tan, Chi Ho Chan, Michael Maleska, Bryan Banuelos Jara, Brian K Lohman, Nathan J Ricks, Daniel R Bond, Ming C Hammond

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhesen TanDepartment of Chemistry and Center for Cell & Genome Science, University of Utah, Salt Lake City, UT 84112, USA.
Chi Ho ChanDepartment of Plant and Microbial Biology and BioTechnology Institute, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-6596-3436
Michael MaleskaDepartment of Plant and Microbial Biology and BioTechnology Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Bryan Banuelos JaraDepartment of Chemistry and Center for Cell & Genome Science, University of Utah, Salt Lake City, UT 84112, USA.
Brian K LohmanHuntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
Nathan J RicksDepartment of Chemistry and Center for Cell & Genome Science, University of Utah, Salt Lake City, UT 84112, USA.
Daniel R BondDepartment of Plant and Microbial Biology and BioTechnology Institute, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0001-8083-7107
Ming C HammondDepartment of Chemistry and Center for Cell & Genome Science, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0003-2666-4764

Funding

Enabling High-Throughput Analysis and Single-Cell Imaging of Bacterial SignalsR01GM124589 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI HAMMOND, MING CHEN · 2017 to 2025
$2.8M
National Science Foundation 1714196National Science Foundation 1915466NIGMS NIH HHS R01 GM124589NIH HHS GM124589
6 · The paper itself

Abstract

The Hypr cGAMP signaling pathway was discovered via the function of the riboswitch. In this study, we show the development of a method for affinity capture followed by sequencing to identify non-coding RNA regions that bind nucleotide signals such as cGAMP. The RNAseq of affinity-captured cGAMP riboswitches from the

Indexed as

MutationRiboswitchTranscriptomeBacterial ProteinsGeobacterNucleotides, CyclicNucleotidyltransferasesSignal TransductionBacterial Proteinscyclic guanosine monophosphate-adenosine monophosphateNucleotides, CyclicNucleotidyltransferasesRiboswitchbacterial signalingbiosensorcyclic dinucleotidereporterriboswitch

Identifiers

PMID35163114
PMCPMC8835794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.