Evidence map›Paper›PMID 35163045›Full record

ArticleInternational journal of molecular sciences2022

Temporal Gene Expression Profiles Reflect the Dynamics of Lymphoid Differentiation.

Smahane Chalabi, Agnes Legrand, Victoria Michaels, Marie-Ange Palomares, Robert Olaso, Anne Boland, Jean-François Deleuze, Sophie Ezine, Christophe Battail, Diana Tronik-Le Roux

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Smahane ChalabiCentre National de Recherche en Génomique Humaine, CEA, Université Paris-Saclay, 91057 Evry, France.
Agnes LegrandINSERM, Unité 1151, Université De Paris, Unité Mixte de Recherche 8253, 75015 Paris, France.
Victoria MichaelsINSERM, Unité 1151, Université De Paris, Unité Mixte de Recherche 8253, 75015 Paris, France.
Marie-Ange PalomaresCentre National de Recherche en Génomique Humaine, CEA, Université Paris-Saclay, 91057 Evry, France.
Robert OlasoCentre National de Recherche en Génomique Humaine, CEA, Université Paris-Saclay, 91057 Evry, France.
Anne BolandCentre National de Recherche en Génomique Humaine, CEA, Université Paris-Saclay, 91057 Evry, France.ORCID 0000-0001-8789-5676
Jean-François DeleuzeCentre National de Recherche en Génomique Humaine, CEA, Université Paris-Saclay, 91057 Evry, France.
Sophie EzineINSERM, Unité 1151, Université De Paris, Unité Mixte de Recherche 8253, 75015 Paris, France.
Christophe BattailCentre National de Recherche en Génomique Humaine, CEA, Université Paris-Saclay, 91057 Evry, France.ORCID 0000-0001-6849-7824
Diana Tronik-Le RouxAtomic Energy and Alternative Energies Agency (CEA), Department of Research in Hemato-Immunology (SRHI), Saint-Louis Hospital, 75010 Paris, France.
Commissariat à l'Énergie Atomique et aux Énergies Alternatives · FRInserm · FRAgence internationale de l'énergie · FR

Funding

Fondation pour la Recherche Médicale DBI20131228570
6 · The paper itself

Abstract

Understanding the emergence of lymphoid committed cells from multipotent progenitors (MPP) is a great challenge in hematopoiesis. To gain deeper insight into the dynamic expression changes associated with these transitions, we report the quantitative transcriptome of two MPP subsets and the common lymphoid progenitor (CLP). While the transcriptome is rather stable between MPP2 and MPP3, expression changes increase with differentiation. Among those, we found that pioneer lymphoid genes such as

Indexed as

Gene Regulatory NetworksHematopoiesisAnimalsCells, CulturedFemaleGene Expression ProfilingGene Expression RegulationGenetic MarkersHigh-Throughput Nucleotide SequencingLymphoid Progenitor CellsMaleMiceRNA, Long NoncodingSequence Analysis, RNAGenetic MarkersRNA, Long Noncodinggene networkshematopoietic differentiationlong non-coding RNAlymphopoiesisRNAseqtranscriptome

Identifiers

PMID35163045
PMCPMC8834919
OpenAlexW4205214463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.