Evidence map›Paper›PMID 35162994›Full record

ArticleInternational journal of molecular sciences2022

Combining Metabolomics and Experimental Evolution Reveals Key Mechanisms Underlying Longevity Differences in Laboratory Evolved

Mark A Phillips, Kenneth R Arnold, Zer Vue, Heather K Beasley, Edgar Garza-Lopez, Andrea G Marshall, Derrick J Morton, Melanie R McReynolds, Thomas T Barter, Antentor Hinton

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Naturally Occurring Variability in the Regulatory Region of theInternational journal of molecular sciences · 2026
    Article
  2. Metabolomic Profiling ofJournal of fungi (Basel, Switzerland) · 2026
    Article
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  11. Ablation ofbioRxiv : the preprint server for biology · 2023
    Article
  12. Article
  13. Mitochondrial Bioenergetics in Different Pathophysiological Conditions 2.0.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mark A PhillipsDepartment of Integrative Biology, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0002-2319-7913
Kenneth R ArnoldDepartment of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA.ORCID 0000-0003-1223-0260
Zer VueDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Heather K BeasleyDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-4636-2889
Edgar Garza-LopezHinton and Garza-Lopez Family Consulting Company, Iowa City, IA 52246, USA.
Andrea G MarshallDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Derrick J MortonDepartment of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Melanie R McReynoldsDepartment of Biochemistry and Molecular Biology, Huck Institute of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.
Thomas T BarterDepartment of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697, USA.ORCID 0000-0003-3374-8181
Antentor HintonDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-7730-952X

Funding

Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3M
THE MEHARRY RISE INITIATIVER25GM059994 · NIGMS · MEHARRY MEDICAL COLLEGE · PI MOTLEY-JOHNSON, EVANGELINE D · 1999 to 2021
$23.0M
Translational Pathology CoreU54CA163069 · NCI · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2011 to 2025
$18.8M
INTERDISCIPLINARY CARDIOVASCULAR RESEARCH FELLOWSHIPT32HL007121 · NHLBI · UNIVERSITY OF IOWA · PI LONDON, BARRY · 1985 to 2020
$15.1M
PRIDE: Functional and Translational Genomics of Blood DisordersR25HL106365 · NHLBI · AUGUSTA UNIVERSITY · PI PACE, BETTY SUE · 2010 to 2024
$5.2M
NCI NIH HHS U54 CA163069NHLBI NIH HHS R25 HL106365NHLBI NIH HHS T32 HL007121NIDDK NIH HHS P30 DK020593NIGMS NIH HHS R25 GM059994
6 · The paper itself

Abstract

Experimental evolution with

Indexed as

AgingAnimalsCarbohydrate MetabolismCitric Acid CycleDirected Molecular EvolutionDrosophila melanogasterGenomicsLongevityMetabolomicsMitochondriaMultifactorial InheritanceNADPolymorphism, Single NucleotideNADagingDrosophila melanogasterevolve and resequenceexperimental evolutiongenomicslife history traitsmetabolomicsmitochondria

Identifiers

PMID35162994
PMCPMC8835531

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.