ArticleInternational journal of environmental research and public health2022
Moderators and Other Predictors of Methylphenidate Response in Children and Adolescents with ADHD.
Article in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A Random Forest-Based Risk Prediction Model for Non-Response to Methylphenidate in Children with Attention Deficit Hyperactivity Disorder.Neuropsychiatric disease and treatment · 2026Article
- Change in vital parameters at first methylphenidate administration as a predictor of treatment response at six-month follow-up.European child & adolescent psychiatry · 2026Article
- From symptom-based heterogeneity to mechanism-based profiling in youth ADHD: the promise of computational psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Predictors of Methylphenidate response in children and adolescents with ADHD: the role of sleep disturbances.European archives of psychiatry and clinical neuroscience · 2025Article
- Can response to ADHD medication be predicted?European child & adolescent psychiatry · 2025Observational
- Methylphenidate is more effective to improve inhibitory control and working memory compared to tDCS in children and adolescents with attention deficit/hyperactivity disorder: a proof-of-concept study.Frontiers in neuroscience · 2023Article
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Authors and funding
6 authors.
Funding
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Abstract
Methylphenidate (MPH) is the treatment of first choice for developmental ADHD. To date, no reliable method to predict how patients will respond to MPH exists and conflicting results are reported on clinical characteristics of responders. The present study aims to give a more precise characterization of the patients who will respond best to MPH to help clinicians in defining the treatment plan. Age, neuropsychological functioning (i.e., attention and working memory), and behavioral/emotional symptoms of 48 drug-naïve children and adolescents with ADHD (42 boys and 6 girls, age-range 6-16 years, mean age 10.5 ± 2.5 years, mean IQ 101.3 ± 11.2) were studied to assess how these different characteristics affected a single-dose MPH response. Four hierarchical linear regression models were used to explore whether age, neuropsychological measures at baseline, and behavioral/emotional symptoms could predict attention and working memory measures after a single-dose MPH administration. We found that improvement in attention and working memory was predicted by age, neuropsychological measures at baseline, and severity of ADHD symptoms. No behavioral and emotional symptoms predicted single-dose MPH response with the exception of conduct symptoms.
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Registered trials
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