SynthesisInternational journal of environmental research and public health2022
A Systematic Review on Nerve-Related Adverse Effects following Mandibular Nerve Block Anesthesia.
Synthesis in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06564987 (Risk of Nerve Damage After Administration of an Inferior Alveolar Nerve Block Using 4% Articaine Versus 2% Lidocaine), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Risk of Nerve Damage After Administration of an Inferior Alveolar Nerve Block Using 4% Articaine Versus 2% Lidocaine
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Optimal needle characteristics for classical inferior alveolar nerve block anesthesia: a systematic review.Head & face medicine · 2025Pooled it
- Predicting alveolar nerve injury and the difficulty level of extraction impacted third molars: a systematic review of deep learning approaches.Frontiers in dental medicine · 2025Pooled it
- Articaine provides a faster onset and longer duration of analgesia at lower supplemental injections compared to mepivacaine in third molar extractions.Oral and maxillofacial surgery · 2025Trial
- Randomized controlled trial evaluating the efficacy of the "water on tray" anesthesia technique compared to the Halsted technique.Clinical oral investigations · 2024Trial
- Comparison of Efficacy of Lidocaine and Articaine as Inferior Alveolar Nerve Blocking Agents in Patients with Symptomatic Irreversible Pulpitis: Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2023Trial
- Aging-Related Changes in the Injury Response of the Peripheral Nervous System.Neuroscience bulletin · 2026Review
- Efficacy of the TuttleNumbNow anesthesia protocol for mandibular first molars: a retrospective study.Journal of dental anesthesia and pain medicine · 2026Article
- Review
- Review
- Evaluating Pain, Onset of Action, Duration, and Anesthetic Efficacy of Conventional and Buffered Lidocaine in Infiltration Anesthesia: A Comparative Clinical Study.Journal of clinical and experimental dentistry · 2025Review
- Impacted Mandibular Third Molar: Approaches and Current Perspectives in Surgical Therapy.Medicina (Kaunas, Lithuania) · 2025Review
- Challenges in Diagnosing the Course of the Lingual Nerve for Clinical Practice and Research.Diagnostics (Basel, Switzerland) · 2025Review
- Challenges in Developing an Effective Inferior Alveolar Nerve Block Guide.Anesthesia progress · 2025Article
- Re-Intervention Rate, Timing, and Indications Following Coronectomy of the Mandibular Third Molar: A Systematic Review of Systematic Reviews.Journal of clinical medicine · 2025Review
- Mental Nerve Paresthesia, a Complication of Anesthesia in Non-surgical Endodontic Treatment: A Case Report .Iranian endodontic journal · 2025Article
- Lingual nerve injuries: recognized complications or preventable errors?Frontiers in oral health · 2025Article
- Comparison of Analgesic Effect of Inferior Alveolar Nerve Block and Lidocaine Infiltration in Posterior Mandibular Implant Placement: A Split-Mouth Randomized Clinical Trial.World journal of plastic surgery · 2025Article
- A new and simplified extraoral approach for inferior alveolar nerve block: a cadaveric study and clinical case reports.Journal of anesthesia · 2024Article
- The Pterygomandibular Space: A Volumetric Evaluation Using the Novel A-Silicone Injections Method.Diagnostics (Basel, Switzerland) · 2024Article
- Introducing a novel intraoral mandibular nerve block technique for loco-regional analgesia in camels (Camelus dromedarius): a cadaveric study using computed tomography.BMC veterinary research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inferior alveolar nerve (IAN) block injections are commonly used in clinical practice, but they are not free from complications. The aim of the present systematic review is to assess the nerve-related adverse effects of IAN block anesthesia. A structured and systematic search was performed on the major electronic databases (PubMed, Cochrane Library, Web of Science, Scopus and CINAHL) for studies published in English until 30 September 2021. A total of 131 articles were identified through database searching using combinations of keywords. Fifteen papers were included and assessed for eligibility. Overall, nerve damage following an IAN block anesthesia injection is a rare occurrence, probably due to the direct nerve trauma of the needle, a neurotoxic effect of the used anesthetic solution and/or a combination of them. From a medico-legal point of view, a balanced discussion prior to nerve block anesthesia should be pursued in order to avoid patients' reluctance to undergo necessary dental treatment due to the remote eventuality of nerve injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.