Evidence map›Paper›PMID 35162238›Full record

SynthesisInternational journal of environmental research and public health2022

Physical Activity Improves Cognition and Activities of Daily Living in Adults with Alzheimer's Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Shengwen Zhou, Sitong Chen, Xiaolei Liu, Yanjie Zhang, Mengxian Zhao, Wenjiao Li

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 12 pooled it
14.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 12 syntheses or guidelines pooled it, 107 citations in OpenAlex.

  1. Pooled it
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  6. Systematic review and meta-analysis of repetitive transcranial magnetic stimulation (rTMS) for activities of daily living in Alzheimer's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
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  13. Trial
  14. Review
  15. Article
  16. Changes in device-measured daily physical activity over one year in memory clinic patients.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026
    Article
  17. Article
  18. Effects of physical exercise on cognitive impairment in patients with Alzheimer's disease, Parkinson's disease or mild cognitive impairment: a systematic review and meta-analysis.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2026
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 3 countries.

Shengwen ZhouDepartment of Chinese Martial Arts, College of Sport Science, Hunan University of Science and Engineering, Yongzhou 425100, China.
Sitong ChenInstitute for Health and Sport, Victoria University, Melbourne 8001, Australia.ORCID 0000-0002-8975-7565
Xiaolei LiuChinese Traditional Regimen Exercise Intervention Research Center, Beijing Sport University, Beijing 100084, China.
Yanjie ZhangHealth and Exercise Science Laboratory, Institute of Sports Science, Seoul National University, Seoul 08826, Korea.ORCID 0000-0002-7964-2326
Mengxian ZhaoSchool of Physical Education, Shenzhen University, Shenzhen 518060, China.
Wenjiao LiPhysical Education Unit, School of Humanities and Social Science, The Chinese University of Hong Kong-Shenzhen, Shenzhen 518172, China.
Beijing Sport University · CNChinese University of Hong Kong, Shenzhen · CNHunan University of Science and Engineering · CNSeoul National University · KRShenzhen University · CNVictoria University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe purpose of this meta-analysis was to examine the effects of physical activity (PA) on cognition and activities of daily living in adults with Alzheimer's Disease (AD).

methodsSix electronic databases (MEDLINE, CINAHL, PsycArticles, SPORTDiscus, EMBASE and CNKI) were used to search for potential studies from inception until October 2021. Randomized controlled trials (RCTs) investigating the effect of physical activity (PA) on cognition and activities of daily living in AD patients compared to a control condition were included. The effect sizes were synthesized using a random effects model with a 95% confidence interval (CI).

resultsSixteen articles including 945 participants (aged 70 to 88 years, 34.6% male) met the inclusion criteria. The pooled effect sizes demonstrated that PA intervention was associated with significant improvements in global cognition (Standard Mean Difference (SMD) = 0.41, 95% CI [0.24, 0.58],

conclusionsThe findings from the current meta-analysis suggested that AD patients can improve their global cognition and Activities of Daily Living (ADL) through engaging in aerobic and mixed exercise (aerobic and anaerobic exercise).

Indexed as

Activities of Daily LivingAlzheimer DiseaseAdultAgedAged, 80 and overCognitionExerciseFemaleHumansMaleRandomized Controlled Trials as Topicactivities of daily livingAlzheimer’s diseasecognitive functionphysical exercise

Identifiers

PMID35162238
PMCPMC8834999
OpenAlexW4206903760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.