Evidence map›Paper›PMID 35162125›Full record

ReviewInternational journal of environmental research and public health2022

Non-Epithelial Ovarian Cancers: How Much Do We Really Know?

Alison Cheung, Sidrah Shah, Jack Parker, Pavandeep Soor, Anu Limbu, Matin Sheriff, Stergios Boussios

Abstract readReview
In one paragraph

Review in International journal of environmental research and public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Open-label phase II clinical trial of orteronel (TAK-700) in metastatic or advanced non-resectable granulosa cell ovarian tumors: the Greko II study (GETHI2013-01).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Trial
  4. Open-label phase II clinical trial of ketoconazole as CYP17 inhibitor in metastatic or advanced non-resectable granulosa cell ovarian tumors: the GREKO (GRanulosa Et KetOconazole) trial, GETHI 2011-03.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Trial
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Malignant germ cells tumor of the ovary.Journal of gynecologic oncology · 2025
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Diagnostic biomarkers in ovarian cancer: advances beyond CA125 and HE4.Therapeutic advances in medical oncology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alison CheungDepartment of Medical Oncology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK.ORCID 0000-0003-3978-3121
Sidrah ShahDepartment of Palliative Care, Guy's and St Thomas' Hospital, Great Maze Pond, London SE1 9RT, UK.ORCID 0000-0002-5402-9875
Jack ParkerDepartment of Medical Oncology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK.
Pavandeep SoorDepartment of Medical Oncology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK.
Anu LimbuDepartment of Medical Oncology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK.
Matin SheriffDepartment of Urology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK.
Stergios BoussiosDepartment of Medical Oncology, Medway NHS Foundation Trust, Windmill Road, Kent ME7 5NY, UK.ORCID 0000-0002-2512-6131

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-epithelial ovarian cancers (NEOC) are a group of uncommon malignancies that mainly includes germ cell tumours (GCT), sex cord-stromal tumours (SCST), and some extremely rare tumours, such as small cell carcinomas and sarcomas. Each of these classifications encompasses multiple histologic subtypes. The aetiology and molecular origins of each sub-group of NEOC require further investigation, and our understanding on the genetic changes should be optimised. In this article, we provide an update on the clinical presentation, pathology, genetics, treatment and survival of the main histological subtypes of the GCT and the SCST, as well as of ovarian small cell carcinomas. We also discuss miRNA expression profiles of NEOC and report the currently active clinical trials that include NEOC.

Indexed as

Neoplasms, Germ Cell and EmbryonalOvarian NeoplasmsSarcomaSex Cord-Gonadal Stromal TumorsCarcinoma, Ovarian EpithelialHumansclinical trialsgerm cell tumourssex cord-stromal tumourssmall cell carcinomas of the ovary

Identifiers

PMID35162125
PMCPMC8834485

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.